The Cdx2 homeobox gene suppresses intestinal tumorigenesis through non–cell-autonomous mechanisms

Developmental genes contribute to cancer, as reported for the homeobox gene Cdx2 playing a tumor suppressor role in the gut. In this study, we show that human colon cancers exhibiting the highest reduction in CDX2 expression belong to the serrated subtype with the worst evolution. In mice, mosaic kn...

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Detalles Bibliográficos
Autores principales: Balbinot, Camille, Armant, Olivier, Elarouci, Nabila, Marisa, Laetitia, Martin, Elisabeth, De Clara, Etienne, Onea, Alina, Deschamps, Jacqueline, Beck, Felix, Freund, Jean-Noël, Duluc, Isabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839756/
https://www.ncbi.nlm.nih.gov/pubmed/29439001
http://dx.doi.org/10.1084/jem.20170934

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