Cargando…

Therapeutically targeting tumor microenvironment–mediated drug resistance in estrogen receptor–positive breast cancer

Drug resistance to approved systemic therapies in estrogen receptor–positive (ER+) breast cancer remains common. We hypothesized that factors present in the human tumor microenvironment (TME) drive drug resistance. Screening of a library of recombinant secreted microenvironmental proteins revealed f...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shee, Kevin, Yang, Wei, Hinds, John W., Hampsch, Riley A., Varn, Frederick S., Traphagen, Nicole A., Patel, Kishan, Cheng, Chao, Jenkins, Nicole P., Kettenbach, Arminja N., Demidenko, Eugene, Owens, Philip, Faber, Anthony C., Golub, Todd R., Straussman, Ravid, Miller, Todd W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839765/ https://www.ncbi.nlm.nih.gov/pubmed/29436393 http://dx.doi.org/10.1084/jem.20171818

Ejemplares similares

Estrogen therapy induces an unfolded protein response to drive cell death in ER+ breast cancer
por: Hosford, Sarah R., et al.
Publicado: (2019)

High estrogen receptor alpha activation confers resistance to estrogen deprivation and is required for therapeutic response to estrogen in breast cancer
por: Traphagen, Nicole A., et al.
Publicado: (2021)

Therapeutic sensitivity to Rac GTPase inhibition requires consequential suppression of mTORC1, AKT, and MEK signaling in breast cancer
por: Hampsch, Riley A., et al.
Publicado: (2017)

Tumor microenvironment induces innate RAF-inhibitor resistance through HGF secretion
por: Straussman, Ravid, et al.
Publicado: (2012)

Estrogen receptor alpha drives mTORC1 inhibitor-induced feedback activation of PI3K/AKT in ER+ breast cancer
por: Yang, Wei, et al.
Publicado: (2018)

Statistical determination of synergy based on Bliss definition of drugs independence
por: Demidenko, Eugene, et al.
Publicado: (2019)

Coordination of Protein Kinase and Phosphoprotein Phosphatase Activities in Mitosis
por: Nasa, Isha, et al.
Publicado: (2018)

Comparative Analysis of Mutant Huntingtin Binding Partners in Yeast Species
por: Zhao, Yanding, et al.
Publicado: (2018)

MHC-IIB Filament Assembly and Cellular Localization Are Governed by the Rod Net Charge
por: Rosenberg, Michael, et al.
Publicado: (2008)

Characterization of the human tumor microbiome reveals tumor-type specific intra-cellular bacteria
por: Livyatan, Ilana, et al.
Publicado: (2020)

A B cell-derived gene expression signature associates with an immunologically active tumor microenvironment and response to immune checkpoint blockade therapy
por: Varn, Frederick S., et al.
Publicado: (2018)

Nocodazole-Induced Expression and Phosphorylation of Anillin and Other Mitotic Proteins Are Decreased in DNA-Dependent Protein Kinase Catalytic Subunit-Deficient Cells and Rescued by Inhibition of the Anaphase-Promoting Complex/Cyclosome with proTAME but Not Apcin
por: Douglas, Pauline, et al.
Publicado: (2020)

Identification of Candidate Casein Kinase 2 Substrates in Mitosis by Quantitative Phosphoproteomics
por: Rusin, Scott F., et al.
Publicado: (2017)

Molecular and epigenetic profiles of BRCA1-like hormone-receptor-positive breast tumors identified with development and application of a copy-number-based classifier
por: Chen, Youdinghuan, et al.
Publicado: (2019)

Phosphoprotein phosphatase activity positively regulates oligomeric pyrin to trigger inflammasome assembly in phagocytes
por: Malik, Haleema S., et al.
Publicado: (2023)

The Candida albicans Cdk8-dependent phosphoproteome reveals repression of hyphal growth through a Flo8-dependent pathway
por: Hollomon, Jeffrey M., et al.
Publicado: (2022)

Application of RNAi-induced gene expression profiles for prognostic prediction in breast cancer
por: Wang, Yue, et al.
Publicado: (2016)

A bifurcated signaling cascade of NIMA-related kinases controls distinct kinesins in anaphase
por: Cullati, Sierra N., et al.
Publicado: (2017)

A mechanism for how Cdr1/Nim1 kinase promotes mitotic entry by inhibiting Wee1
por: Opalko, Hannah E., et al.
Publicado: (2019)

Inducible protein degradation as a strategy to identify Phosphoprotein Phosphatase 6 substrates in RAS-mutant colorectal cancer cells
por: Mariano, Natasha C., et al.
Publicado: (2023)

Inducible Protein Degradation as a Strategy to Identify Phosphoprotein Phosphatase 6 Substrates in RAS-Mutant Colorectal Cancer Cells
por: Mariano, Natasha C., et al.
Publicado: (2023)

Chronic Ethanol Exposure: Pathogenesis of Pulmonary Disease and Dysfunction
por: Traphagen, Nicole, et al.
Publicado: (2015)

Plk1 regulates the kinesin-13 protein Kif2b to promote faithful chromosome segregation
por: Hood, Emily A., et al.
Publicado: (2012)

Yeast vacuolar HOPS, regulated by its kinase, exploits affinities for acidic lipids and Rab:GTP for membrane binding and to catalyze tethering and fusion
por: Orr, Amy, et al.
Publicado: (2015)

HOPS catalyzes the interdependent assembly of each vacuolar SNARE into a SNARE complex
por: Orr, Amy, et al.
Publicado: (2017)

Estrogens, Estrogen Receptors and Tumor Microenvironment in Ovarian Cancer
por: Kozieł, Marta Justyna, et al.
Publicado: (2023)

A complex containing lysine-acetylated actin inhibits the formin INF2
por: Mu, A, et al.
Publicado: (2019)

Coupling of Cdc20 inhibition and activation by BubR1
por: Hein, Jamin B., et al.
Publicado: (2021)

P-Rex1 Expression in Invasive Breast Cancer in relation to Receptor Status and Distant Metastatic Site
por: Marotti, Jonathan D., et al.
Publicado: (2017)

Trailblazing Precision Oncology for Rare Tumor Subtypes
por: Shee, Kevin, et al.
Publicado: (2017)

Proteomic Analysis Shows Synthetic Oleanane Triterpenoid Binds to mTOR
por: Yore, Mark M., et al.
Publicado: (2011)

Neurospora WC-1 Recruits SWI/SNF to Remodel frequency and Initiate a Circadian Cycle
por: Wang, Bin, et al.
Publicado: (2014)

Cigarette Smoke Impairs A(2A) Adenosine Receptor Mediated Wound Repair through Up-regulation of Duox-1 Expression
por: Tian, Zhi, et al.
Publicado: (2017)

The Role of the Estrogen Pathway in the Tumor Microenvironment
por: Rothenberger, Natalie J, et al.
Publicado: (2018)

Regulation of PP2A, PP4, and PP6 holoenzyme assembly by carboxyl-terminal methylation
por: Lyons, Scott P., et al.
Publicado: (2021)

Myosin II proteins are required for organization of calcium-induced actin networks upstream of mitochondrial division
por: Kage, Frieda, et al.
Publicado: (2022)

Genome-Wide Mapping Indicates That p73 and p63 Co-Occupy Target Sites and Have Similar DNA-Binding Profiles In Vivo
por: Yang, Annie, et al.
Publicado: (2010)

Rab40c regulates focal adhesions and PP6 activity by controlling ANKRD28 ubiquitylation
por: Han, Ke-Jun, et al.
Publicado: (2022)

Receptor‐mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy
por: Ohnstad, Amelia E, et al.
Publicado: (2020)

Estrogens and the Schrödinger’s Cat in the Ovarian Tumor Microenvironment
por: Gjorgoska, Marija, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_u8lbcb6kspon75hotb8ifrduau