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Metaplastic Cdx2-depleted cells can be very disruptive neighbors
In this issue of JEM, Balbinot et al. (https://doi.org/10.1084/jem.20170934) describe an original mechanism where Cdx2 inactivation regulates intestinal metaplastic to neoplastic transition in a paracrine fashion. Surprisingly, the target cells are neighboring “normal” Cdx2-positive cells.
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Rockefeller University Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839770/ https://www.ncbi.nlm.nih.gov/pubmed/29440363 http://dx.doi.org/10.1084/jem.20180215 |
| _version_ | 1783304458729422848 |
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| author | Lourenço, Filipe C. Winton, Douglas J. |
| author_facet | Lourenço, Filipe C. Winton, Douglas J. |
| author_sort | Lourenço, Filipe C. |
| collection | PubMed |
| description | In this issue of JEM, Balbinot et al. (https://doi.org/10.1084/jem.20170934) describe an original mechanism where Cdx2 inactivation regulates intestinal metaplastic to neoplastic transition in a paracrine fashion. Surprisingly, the target cells are neighboring “normal” Cdx2-positive cells. |
| format | Online Article Text |
| id | pubmed-5839770 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| publisher | Rockefeller University Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-58397702018-09-05 Metaplastic Cdx2-depleted cells can be very disruptive neighbors Lourenço, Filipe C. Winton, Douglas J. J Exp Med News In this issue of JEM, Balbinot et al. (https://doi.org/10.1084/jem.20170934) describe an original mechanism where Cdx2 inactivation regulates intestinal metaplastic to neoplastic transition in a paracrine fashion. Surprisingly, the target cells are neighboring “normal” Cdx2-positive cells. Rockefeller University Press 2018-03-05 /pmc/articles/PMC5839770/ /pubmed/29440363 http://dx.doi.org/10.1084/jem.20180215 Text en © 2018 Lourenço and Winton http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/). |
| spellingShingle | News Lourenço, Filipe C. Winton, Douglas J. Metaplastic Cdx2-depleted cells can be very disruptive neighbors |
| title | Metaplastic Cdx2-depleted cells can be very disruptive neighbors |
| title_full | Metaplastic Cdx2-depleted cells can be very disruptive neighbors |
| title_fullStr | Metaplastic Cdx2-depleted cells can be very disruptive neighbors |
| title_full_unstemmed | Metaplastic Cdx2-depleted cells can be very disruptive neighbors |
| title_short | Metaplastic Cdx2-depleted cells can be very disruptive neighbors |
| title_sort | metaplastic cdx2-depleted cells can be very disruptive neighbors |
| topic | News |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839770/ https://www.ncbi.nlm.nih.gov/pubmed/29440363 http://dx.doi.org/10.1084/jem.20180215 |
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