Defusing inflammasomes

In this issue of JEM, Boucher et al. (https://doi.org/10.1084/jem.20172222) report isolation of active caspase-1 from macrophages after inflammasome activation. Surprisingly, they find that caspase-1 is quickly inactivated upon autoproteolytic processing.

Detalles Bibliográficos
Autores principales: Sandstrom, Andrew, Vance, Russell E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
News
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839772/
https://www.ncbi.nlm.nih.gov/pubmed/29440361
http://dx.doi.org/10.1084/jem.20180241
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author Sandstrom, Andrew
Vance, Russell E.
author_facet Sandstrom, Andrew
Vance, Russell E.
author_sort Sandstrom, Andrew
collection PubMed
description In this issue of JEM, Boucher et al. (https://doi.org/10.1084/jem.20172222) report isolation of active caspase-1 from macrophages after inflammasome activation. Surprisingly, they find that caspase-1 is quickly inactivated upon autoproteolytic processing.
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spelling pubmed-58397722018-09-05 Defusing inflammasomes Sandstrom, Andrew Vance, Russell E. J Exp Med News In this issue of JEM, Boucher et al. (https://doi.org/10.1084/jem.20172222) report isolation of active caspase-1 from macrophages after inflammasome activation. Surprisingly, they find that caspase-1 is quickly inactivated upon autoproteolytic processing. Rockefeller University Press 2018-03-05 /pmc/articles/PMC5839772/ /pubmed/29440361 http://dx.doi.org/10.1084/jem.20180241 Text en © 2018 Sandstrom and Vance http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle News
Sandstrom, Andrew
Vance, Russell E.
Defusing inflammasomes
title Defusing inflammasomes
title_full Defusing inflammasomes
title_fullStr Defusing inflammasomes
title_full_unstemmed Defusing inflammasomes
title_short Defusing inflammasomes
title_sort defusing inflammasomes
topic News
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839772/
https://www.ncbi.nlm.nih.gov/pubmed/29440361
http://dx.doi.org/10.1084/jem.20180241
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