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Brr6 and Brl1 locate to nuclear pore complex assembly sites to promote their biogenesis

The paralogous Brr6 and Brl1 are conserved integral membrane proteins of the nuclear envelope (NE) with an unclear role in nuclear pore complex (NPC) biogenesis. Here, we analyzed double-degron mutants of Brr6/Brl1 to understand this function. Depletion of Brr6 and Brl1 caused defects in NPC biogene...

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Detalles Bibliográficos
Autores principales:	Zhang, Wanlu, Neuner, Annett, Rüthnick, Diana, Sachsenheimer, Timo, Lüchtenborg, Christian, Brügger, Britta, Schiebel, Elmar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839787/ https://www.ncbi.nlm.nih.gov/pubmed/29439116 http://dx.doi.org/10.1083/jcb.201706024

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