Mechanism of Stx17 recruitment to autophagosomes via IRGM and mammalian Atg8 proteins

Autophagy is a conserved eukaryotic process with metabolic, immune, and general homeostatic functions in mammalian cells. Mammalian autophagosomes fuse with lysosomes in a SNARE-driven process that includes syntaxin 17 (Stx17). How Stx17 translocates to autophagosomes is unknown. In this study, we s...

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Detalles Bibliográficos
Autores principales: Kumar, Suresh, Jain, Ashish, Farzam, Farzin, Jia, Jingyue, Gu, Yuexi, Choi, Seong Won, Mudd, Michal H., Claude-Taupin, Aurore, Wester, Michael J., Lidke, Keith A., Rusten, Tor-Erik, Deretic, Vojo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839791/
https://www.ncbi.nlm.nih.gov/pubmed/29420192
http://dx.doi.org/10.1083/jcb.201708039

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