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Do migrating cells need a nucleus?
How the nucleus affects cell polarity and migration is unclear. In this issue, Graham et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201706097) show that enucleated cells polarize and migrate in two but not three dimensions and propose that the nucleus is a necessary component of the molecu...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Rockefeller University Press
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839803/ https://www.ncbi.nlm.nih.gov/pubmed/29453310 http://dx.doi.org/10.1083/jcb.201802054 |
| Sumario: | How the nucleus affects cell polarity and migration is unclear. In this issue, Graham et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201706097) show that enucleated cells polarize and migrate in two but not three dimensions and propose that the nucleus is a necessary component of the molecular clutch regulating normal mechanical responses. |
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