Do migrating cells need a nucleus?

How the nucleus affects cell polarity and migration is unclear. In this issue, Graham et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201706097) show that enucleated cells polarize and migrate in two but not three dimensions and propose that the nucleus is a necessary component of the molecu...

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Detalles Bibliográficos
Autor principal: Hawkins, Rhoda J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839803/
https://www.ncbi.nlm.nih.gov/pubmed/29453310
http://dx.doi.org/10.1083/jcb.201802054
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author Hawkins, Rhoda J.
author_facet Hawkins, Rhoda J.
author_sort Hawkins, Rhoda J.
collection PubMed
description How the nucleus affects cell polarity and migration is unclear. In this issue, Graham et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201706097) show that enucleated cells polarize and migrate in two but not three dimensions and propose that the nucleus is a necessary component of the molecular clutch regulating normal mechanical responses.
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spelling pubmed-58398032018-09-05 Do migrating cells need a nucleus? Hawkins, Rhoda J. J Cell Biol Commentaries How the nucleus affects cell polarity and migration is unclear. In this issue, Graham et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201706097) show that enucleated cells polarize and migrate in two but not three dimensions and propose that the nucleus is a necessary component of the molecular clutch regulating normal mechanical responses. Rockefeller University Press 2018-03-05 /pmc/articles/PMC5839803/ /pubmed/29453310 http://dx.doi.org/10.1083/jcb.201802054 Text en © 2018 Hawkins http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentaries
Hawkins, Rhoda J.
Do migrating cells need a nucleus?
title Do migrating cells need a nucleus?
title_full Do migrating cells need a nucleus?
title_fullStr Do migrating cells need a nucleus?
title_full_unstemmed Do migrating cells need a nucleus?
title_short Do migrating cells need a nucleus?
title_sort do migrating cells need a nucleus?
topic Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839803/
https://www.ncbi.nlm.nih.gov/pubmed/29453310
http://dx.doi.org/10.1083/jcb.201802054
work_keys_str_mv AT hawkinsrhodaj domigratingcellsneedanucleus

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