Cargando…

Prognostic significance of pulmonary hypertension in patients with cystic fibrosis: A systematic review and meta-analysis

BACKGROUND AND OBJECTIVE: Pulmonary hypertension (PH) is frequently found in advanced parenchymal lung diseases like cystic fibrosis (CF), but the role played by PH in the clinical outcome of CF patients remains unclear. The aim of this study is to determine the influence of PH on survival in the CF...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Diandian, Wang, Bo, Wang, Hao, Liu, Qun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839836/
https://www.ncbi.nlm.nih.gov/pubmed/29443734
http://dx.doi.org/10.1097/MD.0000000000009708
_version_ 1783304474142441472
author Li, Diandian
Wang, Bo
Wang, Hao
Liu, Qun
author_facet Li, Diandian
Wang, Bo
Wang, Hao
Liu, Qun
author_sort Li, Diandian
collection PubMed
description BACKGROUND AND OBJECTIVE: Pulmonary hypertension (PH) is frequently found in advanced parenchymal lung diseases like cystic fibrosis (CF), but the role played by PH in the clinical outcome of CF patients remains unclear. The aim of this study is to determine the influence of PH on survival in the CF population by meta-analysis. METHODS: Publications addressing the associations between PH and overall survival (OS) or other clinical characteristics in CF patients were selected from electronic databases. Odds ratios (ORs) or mean differences (MDs) were used to estimate the association between PH and the clinical characteristics. The hazard ratios (HRs) with 95% confidence interval (CI) were abstracted or calculated to evaluate the association between PH and CF survival outcome. Subgroup analyses were also conducted. RESULTS: Seven studies including 2141 CF patients who met the inclusion criteria were included in our meta-analysis. With respect to clinical features, PH was significantly associated with lower PaO(2) (P < .001), higher PaCO(2) (P = .02), lower forced expiratory volume in 1 second percent (P < .001) and lower forced vital capacity percent (P < .001). However, PH had no significant impact on CF patients’ OS (HR = 1.29, 95% CI 0.81 to 2.06, P = .283). Furthermore, subgroup analyses also showed no evidence of prognostic role of PH in CF patients (all P values >.05). CONCLUSIONS: Our findings suggest that the presence of PH was strongly correlated with worse blood-gas parameters and worse lung function, but surprisingly had no significant prognostic value on survival among CF patients. Further large-scale and prospective studies are needed to confirm these findings.
format Online
Article
Text
id pubmed-5839836
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Wolters Kluwer Health
record_format MEDLINE/PubMed
spelling pubmed-58398362018-03-13 Prognostic significance of pulmonary hypertension in patients with cystic fibrosis: A systematic review and meta-analysis Li, Diandian Wang, Bo Wang, Hao Liu, Qun Medicine (Baltimore) 6700 BACKGROUND AND OBJECTIVE: Pulmonary hypertension (PH) is frequently found in advanced parenchymal lung diseases like cystic fibrosis (CF), but the role played by PH in the clinical outcome of CF patients remains unclear. The aim of this study is to determine the influence of PH on survival in the CF population by meta-analysis. METHODS: Publications addressing the associations between PH and overall survival (OS) or other clinical characteristics in CF patients were selected from electronic databases. Odds ratios (ORs) or mean differences (MDs) were used to estimate the association between PH and the clinical characteristics. The hazard ratios (HRs) with 95% confidence interval (CI) were abstracted or calculated to evaluate the association between PH and CF survival outcome. Subgroup analyses were also conducted. RESULTS: Seven studies including 2141 CF patients who met the inclusion criteria were included in our meta-analysis. With respect to clinical features, PH was significantly associated with lower PaO(2) (P < .001), higher PaCO(2) (P = .02), lower forced expiratory volume in 1 second percent (P < .001) and lower forced vital capacity percent (P < .001). However, PH had no significant impact on CF patients’ OS (HR = 1.29, 95% CI 0.81 to 2.06, P = .283). Furthermore, subgroup analyses also showed no evidence of prognostic role of PH in CF patients (all P values >.05). CONCLUSIONS: Our findings suggest that the presence of PH was strongly correlated with worse blood-gas parameters and worse lung function, but surprisingly had no significant prognostic value on survival among CF patients. Further large-scale and prospective studies are needed to confirm these findings. Wolters Kluwer Health 2018-02-16 /pmc/articles/PMC5839836/ /pubmed/29443734 http://dx.doi.org/10.1097/MD.0000000000009708 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle 6700
Li, Diandian
Wang, Bo
Wang, Hao
Liu, Qun
Prognostic significance of pulmonary hypertension in patients with cystic fibrosis: A systematic review and meta-analysis
title Prognostic significance of pulmonary hypertension in patients with cystic fibrosis: A systematic review and meta-analysis
title_full Prognostic significance of pulmonary hypertension in patients with cystic fibrosis: A systematic review and meta-analysis
title_fullStr Prognostic significance of pulmonary hypertension in patients with cystic fibrosis: A systematic review and meta-analysis
title_full_unstemmed Prognostic significance of pulmonary hypertension in patients with cystic fibrosis: A systematic review and meta-analysis
title_short Prognostic significance of pulmonary hypertension in patients with cystic fibrosis: A systematic review and meta-analysis
title_sort prognostic significance of pulmonary hypertension in patients with cystic fibrosis: a systematic review and meta-analysis
topic 6700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839836/
https://www.ncbi.nlm.nih.gov/pubmed/29443734
http://dx.doi.org/10.1097/MD.0000000000009708
work_keys_str_mv AT lidiandian prognosticsignificanceofpulmonaryhypertensioninpatientswithcysticfibrosisasystematicreviewandmetaanalysis
AT wangbo prognosticsignificanceofpulmonaryhypertensioninpatientswithcysticfibrosisasystematicreviewandmetaanalysis
AT wanghao prognosticsignificanceofpulmonaryhypertensioninpatientswithcysticfibrosisasystematicreviewandmetaanalysis
AT liuqun prognosticsignificanceofpulmonaryhypertensioninpatientswithcysticfibrosisasystematicreviewandmetaanalysis