Toll-like receptor 9 antagonizes antibody affinity maturation

Key events in T cell-dependent antibody responses, including affinity maturation, are dependent on the B cell’s presentation of antigen to helper T cells at critical check points in germinal center formation in secondary lymphoid organs. Here we show that Toll-like receptor 9 (TLR9) signaling blocke...

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Detalles Bibliográficos
Autores principales: Akkaya, Munir, Akkaya, Billur, Kim, Ann S., Miozzo, Pietro, Sohn, Haewon, Pena, Mirna, Roesler, Alexander S., Theall, Brandon P., Henke, Travis, Kabat, Juraj, Lu, Jinghua, Dorward, David W., Dahlstrom, Eric, Skinner, Jeff, Miller, Louis H., Pierce, Susan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839995/
https://www.ncbi.nlm.nih.gov/pubmed/29476183
http://dx.doi.org/10.1038/s41590-018-0052-z

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