2′-O-methylation in mRNA disrupts tRNA decoding during translation elongation

Chemical modifications of messenger RNA (mRNA) may regulate many aspects of mRNA processing and protein synthesis. Recently, 2′-O-methylation of nucleotides was identified as a frequent modification in translated regions of human mRNA, showing enrichment in codons for certain amino acid. Here, using...

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Detalles Bibliográficos
Autores principales: Choi, Junhong, Indrisiunaite, Gabriele, DeMirci, Hasan, Ieong, Ka-Weng, Wang, Jinfan, Petrov, Alexey, Prabhakar, Arjun, Rechavi, Gideon, Dominissini, Dan, He, Chuan, Ehrenberg, Måns, Puglisi, Joseph D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840002/
https://www.ncbi.nlm.nih.gov/pubmed/29459784
http://dx.doi.org/10.1038/s41594-018-0030-z

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