DKK2 imparts tumor immunity evasion through β-catenin-independent suppression of cytotoxic immune cell activation

Immunotherapy offers new cancer treatment options, but efficacy varies across cancer types. Colorectal cancers (CRCs) are largely refractory to immune checkpoint blockade, suggesting the presence of yet-to-be characterized immune suppressive mechanisms. Here we report that APC-loss in intestinal tum...

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Detalles Bibliográficos
Autores principales: Xiao, Qian, Wu, Jibo, Wang, Wei-Jia, Chen, Shiyang, Zheng, Yingxia, Yu, Xiaoqing, Meeth, Katrina, Sahraei, Mahnaz, Bothwell, Alfred L. M., Chen, Lieping, Bosenberg, Marcus, Chen, Jianfeng, Sexl, Veronika, Sun, Le, Li, Lin, Tang, Wenwen, Wu, Dianqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840007/
https://www.ncbi.nlm.nih.gov/pubmed/29431745
http://dx.doi.org/10.1038/nm.4496

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