Structure-Activity Relationship Analysis of 3-Phenylcoumarin-Based Monoamine Oxidase B Inhibitors

Monoamine oxidase B (MAO-B) catalyzes deamination of monoamines such as neurotransmitters dopamine and norepinephrine. Accordingly, small-molecule MAO-B inhibitors potentially alleviate the symptoms of dopamine-linked neuropathologies such as depression or Parkinson's disease. Coumarin with a f...

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Detalles Bibliográficos
Autores principales: Rauhamäki, Sanna, Postila, Pekka A., Niinivehmas, Sanna, Kortet, Sami, Schildt, Emmi, Pasanen, Mira, Manivannan, Elangovan, Ahinko, Mira, Koskimies, Pasi, Nyberg, Niina, Huuskonen, Pasi, Multamäki, Elina, Pasanen, Markku, Juvonen, Risto O., Raunio, Hannu, Huuskonen, Juhani, Pentikäinen, Olli T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840146/
https://www.ncbi.nlm.nih.gov/pubmed/29552556
http://dx.doi.org/10.3389/fchem.2018.00041

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