Granulosa Cell Apoptosis in the Ovarian Follicle—A Changing View

Recent studies challenge the previous view that apoptosis within the granulosa cells of the maturing ovarian follicle is a reflection of aging and consequently a marker for poor quality of the contained oocyte. On the contrary, apoptosis within the granulosa cells is an integral part of normal devel...

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Autores principales: Regan, Sheena L. P., Knight, Phil G., Yovich, John L., Leung, Yee, Arfuso, Frank, Dharmarajan, Arun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840209/
https://www.ncbi.nlm.nih.gov/pubmed/29551992
http://dx.doi.org/10.3389/fendo.2018.00061
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author Regan, Sheena L. P.
Knight, Phil G.
Yovich, John L.
Leung, Yee
Arfuso, Frank
Dharmarajan, Arun
author_facet Regan, Sheena L. P.
Knight, Phil G.
Yovich, John L.
Leung, Yee
Arfuso, Frank
Dharmarajan, Arun
author_sort Regan, Sheena L. P.
collection PubMed
description Recent studies challenge the previous view that apoptosis within the granulosa cells of the maturing ovarian follicle is a reflection of aging and consequently a marker for poor quality of the contained oocyte. On the contrary, apoptosis within the granulosa cells is an integral part of normal development and has limited predictive capability regarding oocyte quality or the ensuing pregnancy rate in in vitro fertilization programs. This review article covers our revised understanding of the process of apoptosis within the ovarian follicle, its three phenotypes, the major signaling pathways underlying apoptosis as well as the associated mitochondrial pathways.
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spelling pubmed-58402092018-03-16 Granulosa Cell Apoptosis in the Ovarian Follicle—A Changing View Regan, Sheena L. P. Knight, Phil G. Yovich, John L. Leung, Yee Arfuso, Frank Dharmarajan, Arun Front Endocrinol (Lausanne) Endocrinology Recent studies challenge the previous view that apoptosis within the granulosa cells of the maturing ovarian follicle is a reflection of aging and consequently a marker for poor quality of the contained oocyte. On the contrary, apoptosis within the granulosa cells is an integral part of normal development and has limited predictive capability regarding oocyte quality or the ensuing pregnancy rate in in vitro fertilization programs. This review article covers our revised understanding of the process of apoptosis within the ovarian follicle, its three phenotypes, the major signaling pathways underlying apoptosis as well as the associated mitochondrial pathways. Frontiers Media S.A. 2018-03-02 /pmc/articles/PMC5840209/ /pubmed/29551992 http://dx.doi.org/10.3389/fendo.2018.00061 Text en Copyright © 2018 Regan, Knight, Yovich, Leung, Arfuso and Dharmarajan. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Regan, Sheena L. P.
Knight, Phil G.
Yovich, John L.
Leung, Yee
Arfuso, Frank
Dharmarajan, Arun
Granulosa Cell Apoptosis in the Ovarian Follicle—A Changing View
title Granulosa Cell Apoptosis in the Ovarian Follicle—A Changing View
title_full Granulosa Cell Apoptosis in the Ovarian Follicle—A Changing View
title_fullStr Granulosa Cell Apoptosis in the Ovarian Follicle—A Changing View
title_full_unstemmed Granulosa Cell Apoptosis in the Ovarian Follicle—A Changing View
title_short Granulosa Cell Apoptosis in the Ovarian Follicle—A Changing View
title_sort granulosa cell apoptosis in the ovarian follicle—a changing view
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840209/
https://www.ncbi.nlm.nih.gov/pubmed/29551992
http://dx.doi.org/10.3389/fendo.2018.00061
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