Involvement of Cellular Prion Protein in α-Synuclein Transport in Neurons

The cellular prion protein, encoded by the gene Prnp, has been reported to be a receptor of β-amyloid. Their interaction is mandatory for neurotoxic effects of β-amyloid oligomers. In this study, we aimed to explore whether the cellular prion protein participates in the spreading of α-synuclein. Res...

Descripción completa

Detalles Bibliográficos
Autores principales: Urrea, Laura, Segura-Feliu, Miriam, Masuda-Suzukake, Masami, Hervera, Arnau, Pedraz, Lucas, García Aznar, José Manuel, Vila, Miquel, Samitier, Josep, Torrents, Eduard, Ferrer, Isidro, Gavín, Rosalina, Hagesawa, Masato, del Río, José Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840251/
https://www.ncbi.nlm.nih.gov/pubmed/28229331
http://dx.doi.org/10.1007/s12035-017-0451-4
_version_ 1783304539676344320
author Urrea, Laura
Segura-Feliu, Miriam
Masuda-Suzukake, Masami
Hervera, Arnau
Pedraz, Lucas
García Aznar, José Manuel
Vila, Miquel
Samitier, Josep
Torrents, Eduard
Ferrer, Isidro
Gavín, Rosalina
Hagesawa, Masato
del Río, José Antonio
author_facet Urrea, Laura
Segura-Feliu, Miriam
Masuda-Suzukake, Masami
Hervera, Arnau
Pedraz, Lucas
García Aznar, José Manuel
Vila, Miquel
Samitier, Josep
Torrents, Eduard
Ferrer, Isidro
Gavín, Rosalina
Hagesawa, Masato
del Río, José Antonio
author_sort Urrea, Laura
collection PubMed
description The cellular prion protein, encoded by the gene Prnp, has been reported to be a receptor of β-amyloid. Their interaction is mandatory for neurotoxic effects of β-amyloid oligomers. In this study, we aimed to explore whether the cellular prion protein participates in the spreading of α-synuclein. Results demonstrate that Prnp expression is not mandatory for α-synuclein spreading. However, although the pathological spreading of α-synuclein can take place in the absence of Prnp, α-synuclein expanded faster in PrP(C)-overexpressing mice. In addition, α-synuclein binds strongly on PrP(C)-expressing cells, suggesting a role in modulating the effect of α-synuclein fibrils. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s12035-017-0451-4) contains supplementary material, which is available to authorized users.
format Online
Article
Text
id pubmed-5840251
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Springer US
record_format MEDLINE/PubMed
spelling pubmed-58402512018-03-12 Involvement of Cellular Prion Protein in α-Synuclein Transport in Neurons Urrea, Laura Segura-Feliu, Miriam Masuda-Suzukake, Masami Hervera, Arnau Pedraz, Lucas García Aznar, José Manuel Vila, Miquel Samitier, Josep Torrents, Eduard Ferrer, Isidro Gavín, Rosalina Hagesawa, Masato del Río, José Antonio Mol Neurobiol Article The cellular prion protein, encoded by the gene Prnp, has been reported to be a receptor of β-amyloid. Their interaction is mandatory for neurotoxic effects of β-amyloid oligomers. In this study, we aimed to explore whether the cellular prion protein participates in the spreading of α-synuclein. Results demonstrate that Prnp expression is not mandatory for α-synuclein spreading. However, although the pathological spreading of α-synuclein can take place in the absence of Prnp, α-synuclein expanded faster in PrP(C)-overexpressing mice. In addition, α-synuclein binds strongly on PrP(C)-expressing cells, suggesting a role in modulating the effect of α-synuclein fibrils. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s12035-017-0451-4) contains supplementary material, which is available to authorized users. Springer US 2017-02-22 2018 /pmc/articles/PMC5840251/ /pubmed/28229331 http://dx.doi.org/10.1007/s12035-017-0451-4 Text en © The Author(s) 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Article
Urrea, Laura
Segura-Feliu, Miriam
Masuda-Suzukake, Masami
Hervera, Arnau
Pedraz, Lucas
García Aznar, José Manuel
Vila, Miquel
Samitier, Josep
Torrents, Eduard
Ferrer, Isidro
Gavín, Rosalina
Hagesawa, Masato
del Río, José Antonio
Involvement of Cellular Prion Protein in α-Synuclein Transport in Neurons
title Involvement of Cellular Prion Protein in α-Synuclein Transport in Neurons
title_full Involvement of Cellular Prion Protein in α-Synuclein Transport in Neurons
title_fullStr Involvement of Cellular Prion Protein in α-Synuclein Transport in Neurons
title_full_unstemmed Involvement of Cellular Prion Protein in α-Synuclein Transport in Neurons
title_short Involvement of Cellular Prion Protein in α-Synuclein Transport in Neurons
title_sort involvement of cellular prion protein in α-synuclein transport in neurons
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840251/
https://www.ncbi.nlm.nih.gov/pubmed/28229331
http://dx.doi.org/10.1007/s12035-017-0451-4
work_keys_str_mv AT urrealaura involvementofcellularprionproteininasynucleintransportinneurons
AT segurafeliumiriam involvementofcellularprionproteininasynucleintransportinneurons
AT masudasuzukakemasami involvementofcellularprionproteininasynucleintransportinneurons
AT herveraarnau involvementofcellularprionproteininasynucleintransportinneurons
AT pedrazlucas involvementofcellularprionproteininasynucleintransportinneurons
AT garciaaznarjosemanuel involvementofcellularprionproteininasynucleintransportinneurons
AT vilamiquel involvementofcellularprionproteininasynucleintransportinneurons
AT samitierjosep involvementofcellularprionproteininasynucleintransportinneurons
AT torrentseduard involvementofcellularprionproteininasynucleintransportinneurons
AT ferrerisidro involvementofcellularprionproteininasynucleintransportinneurons
AT gavinrosalina involvementofcellularprionproteininasynucleintransportinneurons
AT hagesawamasato involvementofcellularprionproteininasynucleintransportinneurons
AT delriojoseantonio involvementofcellularprionproteininasynucleintransportinneurons

Ejemplares similares