Characterization of gene regulation and protein interaction networks for Matrin 3 encoding mutations linked to amyotrophic lateral sclerosis and myopathy

To understand how mutations in Matrin 3 (MATR3) cause amyotrophic lateral sclerosis (ALS) and distal myopathy, we used transcriptome and interactome analysis, coupled with microscopy. Over-expression of wild-type (WT) or F115C mutant MATR3 had little impact on gene expression in neuroglia cells. Onl...

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Detalles Bibliográficos
Autores principales: Iradi, M. Carolina Gallego, Triplett, Judy C., Thomas, James D., Davila, Rachel, Crown, Anthony M., Brown, Hilda, Lewis, Jada, Swanson, Maurice S., Xu, Guilian, Rodriguez-Lebron, Edgardo, Borchelt, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840295/
https://www.ncbi.nlm.nih.gov/pubmed/29511296
http://dx.doi.org/10.1038/s41598-018-21371-4

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