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Intra-articular dexmedetomidine in knee arthroscopy: A systematic review and meta-analysis

The aim of this meta-analysis is to evaluate the analgesic effects of intra-articular dexmedetomidine (DEX) in arthroscopic knee surgery. A comprehensive literature search was conducted to identify randomized controlled trials (RCTs) comparing intra-articular DEX versus control for postoperative ana...

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Autores principales: Peng, Ke, Chen, Wei-rong, Meng, Xiao-wen, Zhang, Juan, Ji, Fu-hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840390/
https://www.ncbi.nlm.nih.gov/pubmed/29511256
http://dx.doi.org/10.1038/s41598-018-22482-8
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author Peng, Ke
Chen, Wei-rong
Meng, Xiao-wen
Zhang, Juan
Ji, Fu-hai
author_facet Peng, Ke
Chen, Wei-rong
Meng, Xiao-wen
Zhang, Juan
Ji, Fu-hai
author_sort Peng, Ke
collection PubMed
description The aim of this meta-analysis is to evaluate the analgesic effects of intra-articular dexmedetomidine (DEX) in arthroscopic knee surgery. A comprehensive literature search was conducted to identify randomized controlled trials (RCTs) comparing intra-articular DEX versus control for postoperative analgesia in knee arthroscopy. Trial sequential analysis (TSA) was applied to determine the reliability of the evidence. Twelve RCTs including 594 patients met the eligibility criteria. DEX treatment significantly improved postoperative pain outcomes, with weighted mean differences (95% confidence interval) between the DEX and control groups of −1.57 (−1.94 to −1.20, P < 0.00001) for pain scores at rest at postoperative 1 h, −8.54 mg (−11.96 to −5.13, P < 0.00001) for morphine-equivalents at postoperative 0–24 h, and 257.57 min (209.86 to 305.28, P < 0.00001) for time to first request for postoperative analgesia. TSA indicated there is sufficient evidence for these outcomes. Intra-articular DEX did not affect the incidence of postoperative nausea and vomiting, hypotension, bradycardia, or somnolence. This meta-analysis demonstrated that intra-articular administration of DEX improved pain outcomes in the early postoperative period after knee arthroscopy. Due to the limited number of trials and patients included in this meta-analysis, more evidence is required to confirm these findings.
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spelling pubmed-58403902018-03-13 Intra-articular dexmedetomidine in knee arthroscopy: A systematic review and meta-analysis Peng, Ke Chen, Wei-rong Meng, Xiao-wen Zhang, Juan Ji, Fu-hai Sci Rep Article The aim of this meta-analysis is to evaluate the analgesic effects of intra-articular dexmedetomidine (DEX) in arthroscopic knee surgery. A comprehensive literature search was conducted to identify randomized controlled trials (RCTs) comparing intra-articular DEX versus control for postoperative analgesia in knee arthroscopy. Trial sequential analysis (TSA) was applied to determine the reliability of the evidence. Twelve RCTs including 594 patients met the eligibility criteria. DEX treatment significantly improved postoperative pain outcomes, with weighted mean differences (95% confidence interval) between the DEX and control groups of −1.57 (−1.94 to −1.20, P < 0.00001) for pain scores at rest at postoperative 1 h, −8.54 mg (−11.96 to −5.13, P < 0.00001) for morphine-equivalents at postoperative 0–24 h, and 257.57 min (209.86 to 305.28, P < 0.00001) for time to first request for postoperative analgesia. TSA indicated there is sufficient evidence for these outcomes. Intra-articular DEX did not affect the incidence of postoperative nausea and vomiting, hypotension, bradycardia, or somnolence. This meta-analysis demonstrated that intra-articular administration of DEX improved pain outcomes in the early postoperative period after knee arthroscopy. Due to the limited number of trials and patients included in this meta-analysis, more evidence is required to confirm these findings. Nature Publishing Group UK 2018-03-06 /pmc/articles/PMC5840390/ /pubmed/29511256 http://dx.doi.org/10.1038/s41598-018-22482-8 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Peng, Ke
Chen, Wei-rong
Meng, Xiao-wen
Zhang, Juan
Ji, Fu-hai
Intra-articular dexmedetomidine in knee arthroscopy: A systematic review and meta-analysis
title Intra-articular dexmedetomidine in knee arthroscopy: A systematic review and meta-analysis
title_full Intra-articular dexmedetomidine in knee arthroscopy: A systematic review and meta-analysis
title_fullStr Intra-articular dexmedetomidine in knee arthroscopy: A systematic review and meta-analysis
title_full_unstemmed Intra-articular dexmedetomidine in knee arthroscopy: A systematic review and meta-analysis
title_short Intra-articular dexmedetomidine in knee arthroscopy: A systematic review and meta-analysis
title_sort intra-articular dexmedetomidine in knee arthroscopy: a systematic review and meta-analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840390/
https://www.ncbi.nlm.nih.gov/pubmed/29511256
http://dx.doi.org/10.1038/s41598-018-22482-8
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