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Intra-articular dexmedetomidine in knee arthroscopy: A systematic review and meta-analysis
The aim of this meta-analysis is to evaluate the analgesic effects of intra-articular dexmedetomidine (DEX) in arthroscopic knee surgery. A comprehensive literature search was conducted to identify randomized controlled trials (RCTs) comparing intra-articular DEX versus control for postoperative ana...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840390/ https://www.ncbi.nlm.nih.gov/pubmed/29511256 http://dx.doi.org/10.1038/s41598-018-22482-8 |
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author | Peng, Ke Chen, Wei-rong Meng, Xiao-wen Zhang, Juan Ji, Fu-hai |
author_facet | Peng, Ke Chen, Wei-rong Meng, Xiao-wen Zhang, Juan Ji, Fu-hai |
author_sort | Peng, Ke |
collection | PubMed |
description | The aim of this meta-analysis is to evaluate the analgesic effects of intra-articular dexmedetomidine (DEX) in arthroscopic knee surgery. A comprehensive literature search was conducted to identify randomized controlled trials (RCTs) comparing intra-articular DEX versus control for postoperative analgesia in knee arthroscopy. Trial sequential analysis (TSA) was applied to determine the reliability of the evidence. Twelve RCTs including 594 patients met the eligibility criteria. DEX treatment significantly improved postoperative pain outcomes, with weighted mean differences (95% confidence interval) between the DEX and control groups of −1.57 (−1.94 to −1.20, P < 0.00001) for pain scores at rest at postoperative 1 h, −8.54 mg (−11.96 to −5.13, P < 0.00001) for morphine-equivalents at postoperative 0–24 h, and 257.57 min (209.86 to 305.28, P < 0.00001) for time to first request for postoperative analgesia. TSA indicated there is sufficient evidence for these outcomes. Intra-articular DEX did not affect the incidence of postoperative nausea and vomiting, hypotension, bradycardia, or somnolence. This meta-analysis demonstrated that intra-articular administration of DEX improved pain outcomes in the early postoperative period after knee arthroscopy. Due to the limited number of trials and patients included in this meta-analysis, more evidence is required to confirm these findings. |
format | Online Article Text |
id | pubmed-5840390 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-58403902018-03-13 Intra-articular dexmedetomidine in knee arthroscopy: A systematic review and meta-analysis Peng, Ke Chen, Wei-rong Meng, Xiao-wen Zhang, Juan Ji, Fu-hai Sci Rep Article The aim of this meta-analysis is to evaluate the analgesic effects of intra-articular dexmedetomidine (DEX) in arthroscopic knee surgery. A comprehensive literature search was conducted to identify randomized controlled trials (RCTs) comparing intra-articular DEX versus control for postoperative analgesia in knee arthroscopy. Trial sequential analysis (TSA) was applied to determine the reliability of the evidence. Twelve RCTs including 594 patients met the eligibility criteria. DEX treatment significantly improved postoperative pain outcomes, with weighted mean differences (95% confidence interval) between the DEX and control groups of −1.57 (−1.94 to −1.20, P < 0.00001) for pain scores at rest at postoperative 1 h, −8.54 mg (−11.96 to −5.13, P < 0.00001) for morphine-equivalents at postoperative 0–24 h, and 257.57 min (209.86 to 305.28, P < 0.00001) for time to first request for postoperative analgesia. TSA indicated there is sufficient evidence for these outcomes. Intra-articular DEX did not affect the incidence of postoperative nausea and vomiting, hypotension, bradycardia, or somnolence. This meta-analysis demonstrated that intra-articular administration of DEX improved pain outcomes in the early postoperative period after knee arthroscopy. Due to the limited number of trials and patients included in this meta-analysis, more evidence is required to confirm these findings. Nature Publishing Group UK 2018-03-06 /pmc/articles/PMC5840390/ /pubmed/29511256 http://dx.doi.org/10.1038/s41598-018-22482-8 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Peng, Ke Chen, Wei-rong Meng, Xiao-wen Zhang, Juan Ji, Fu-hai Intra-articular dexmedetomidine in knee arthroscopy: A systematic review and meta-analysis |
title | Intra-articular dexmedetomidine in knee arthroscopy: A systematic review and meta-analysis |
title_full | Intra-articular dexmedetomidine in knee arthroscopy: A systematic review and meta-analysis |
title_fullStr | Intra-articular dexmedetomidine in knee arthroscopy: A systematic review and meta-analysis |
title_full_unstemmed | Intra-articular dexmedetomidine in knee arthroscopy: A systematic review and meta-analysis |
title_short | Intra-articular dexmedetomidine in knee arthroscopy: A systematic review and meta-analysis |
title_sort | intra-articular dexmedetomidine in knee arthroscopy: a systematic review and meta-analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840390/ https://www.ncbi.nlm.nih.gov/pubmed/29511256 http://dx.doi.org/10.1038/s41598-018-22482-8 |
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