Cargando…

Gene-by-environment interactions in urban populations modulate risk phenotypes

Uncovering the interaction between genomes and the environment is a principal challenge of modern genomics and preventive medicine. While theoretical models are well defined, little is known of the G × E interactions in humans. We used an integrative approach to comprehensively assess the interactio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Favé, Marie-Julie, Lamaze, Fabien C., Soave, David, Hodgkinson, Alan, Gauvin, Héloïse, Bruat, Vanessa, Grenier, Jean-Christophe, Gbeha, Elias, Skead, Kimberly, Smargiassi, Audrey, Johnson, Markey, Idaghdour, Youssef, Awadalla, Philip
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840419/ https://www.ncbi.nlm.nih.gov/pubmed/29511166 http://dx.doi.org/10.1038/s41467-018-03202-2

Ejemplares similares

Genomic architecture of sickle cell disease in West African children
por: Quinlan, Jacklyn, et al.
Publicado: (2014)

Recombination affects allele-specific expression of deleterious variants in human populations
por: Harwood, Michelle P., et al.
Publicado: (2022)

A haplotype-based normalization technique for the analysis and detection of allele specific expression
por: Hodgkinson, Alan, et al.
Publicado: (2016)

Aberrant PRDM9 expression impacts the pan-cancer genomic landscape
por: Houle, Armande Ang, et al.
Publicado: (2018)

Comparative Analysis of Iron Homeostasis in Sub-Saharan African Children with Sickle Cell Disease and Their Unaffected Siblings
por: Gomez, Selma, et al.
Publicado: (2016)

Interacting evolutionary pressures drive mutation dynamics and health outcomes in aging blood
por: Skead, Kimberly, et al.
Publicado: (2021)

Exploiting Gene Expression Variation to Capture Gene-Environment Interactions for Disease
por: Idaghdour, Youssef, et al.
Publicado: (2013)

Whole-Exome Sequencing Reveals a Rapid Change in the Frequency of Rare Functional Variants in a Founding Population of Humans
por: Casals, Ferran, et al.
Publicado: (2013)

Selective constraint, background selection, and mutation accumulation variability within and between human populations
por: Hodgkinson, Alan, et al.
Publicado: (2013)

Integrated genomic analysis of mitochondrial RNA processing in human cancers
por: Idaghdour, Youssef, et al.
Publicado: (2017)

Rare allelic forms of PRDM9 associated with childhood leukemogenesis
por: Hussin, Julie, et al.
Publicado: (2013)

Analysis of mitochondrial m1A/G RNA modification reveals links to nuclear genetic variants and associated disease processes
por: Ali, Aminah Tasnim, et al.
Publicado: (2020)

Costing universal health coverage
por: Wong, Joseph, et al.
Publicado: (2019)

The associations between malaria, interventions, and the environment: a systematic review and meta-analysis
por: Sadoine, Margaux L., et al.
Publicado: (2018)

Long-term exposure to a mixture of industrial SO(2), NO(2), and PM(2.5) and anti-citrullinated protein antibody positivity
por: Zhao, Naizhuo, et al.
Publicado: (2020)

Strong variations in urban allergenicity riskscapes due to poor knowledge of tree pollen allergenic potential
por: Sousa-Silva, Rita, et al.
Publicado: (2021)

Quantifying Vulnerability to Extreme Heat in Time Series Analyses: A Novel Approach Applied to Neighborhood Social Disparities under Climate Change
por: Benmarhnia, Tarik, et al.
Publicado: (2015)

Pan-cancer classification of single cells in the tumour microenvironment
por: Nofech-Mozes, Ido, et al.
Publicado: (2023)

On the proportional hazards model for occupational and environmental case-control analyses
por: Gauvin, Héloïse, et al.
Publicado: (2013)

Provincial variation in colorectal cancer screening adherence in Canada; evidence from the Canadian Partnership for Tomorrow’s Health
por: Darvishian, Maryam, et al.
Publicado: (2023)

Falcon genomics in the context of conservation, speciation, and human culture
por: Wilcox, Justin J. S., et al.
Publicado: (2019)

Stocking impacts the expression of candidate genes and physiological condition in introgressed brook charr (Salvelinus fontinalis) populations
por: Lamaze, Fabien C, et al.
Publicado: (2013)

Creation and testing of the Domiscore—a tool to characterize the impact of housing on health and well-being
por: Richard, Aude, et al.
Publicado: (2023)

Interferon Gamma Receptor: The Beginning of the Journey
por: Blouin, Cédric M., et al.
Publicado: (2013)

“Is there anything good about a water advisory?”: an exploration of the consequences of drinking water advisories in an indigenous community
por: Lucier, Kayla J., et al.
Publicado: (2020)

Comparing the accuracy of food outlet datasets in an urban environment
por: Wong, Michelle S., et al.
Publicado: (2017)

Harnessing the power of data linkage to enrich the cancer research ecosystem in Canada.
por: Urquhart, Robin, et al.
Publicado: (2022)

Variation of daily warm season mortality as a function of micro-urban heat islands
por: Smargiassi, A, et al.
Publicado: (2009)

Early urban impact on Mediterranean coastal environments
por: Kaniewski, David, et al.
Publicado: (2013)

The influence of the environment and indoor residual spraying on malaria risk in a cohort of children in Uganda
por: Sadoine, Margaux L., et al.
Publicado: (2022)

Obesity and Urban Environments
por: Congdon, Peter
Publicado: (2019)

metagene Profiles Analyses Reveal Regulatory Element’s Factor-Specific Recruitment Patterns
por: Joly Beauparlant, Charles, et al.
Publicado: (2016)

A Genome-Wide Gene Expression Signature of Environmental Geography in Leukocytes of Moroccan Amazighs
por: Idaghdour, Youssef, et al.
Publicado: (2008)

Epigenetic therapy of acute myeloid leukemia using 5-aza-2'-deoxycytidine (decitabine) in combination with inhibitors of histone methylation and deacetylation
por: Momparler, Richard L, et al.
Publicado: (2014)

Inhibition of DNA and Histone Methylation by 5-Aza-2′-Deoxycytidine (Decitabine) and 3-Deazaneplanocin-A on Antineoplastic Action and Gene Expression in Myeloid Leukemic Cells
por: Momparler, Richard L., et al.
Publicado: (2017)

Cardiovascular health, traffic-related air pollution and noise: are associations mutually confounded? A systematic review
por: Tétreault, Louis-François, et al.
Publicado: (2013)

Healthy urban environments for children and young people: A systematic review of intervention studies
por: Audrey, Suzanne, et al.
Publicado: (2015)

Allele-specific expression reveals interactions between genetic variation and environment
por: Knowles, David A., et al.
Publicado: (2017)

Children and their urban environment : changing worlds
por: Freeman, Claire
Publicado: (2011)

Exome sequencing identifies mutations in the gene TTC7A in French-Canadian cases with hereditary multiple intestinal atresia
por: Samuels, Mark E, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_f0tndel3h6b5b17ko5ri03v9ho