Nitrite as a pharmacological intervention for the successful treatment of crush syndrome

Crush syndrome is characterized by ischemia/reperfusion injury (IRI). The protective effect of nitrite on experimentally induced IRI has been demonstrated in the heart, kidney, liver, and skeletal muscle. IRI in tissues and systemic organs occurs due to the massive generation of reactive oxygen spec...

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Detalles Bibliográficos
Autores principales: Kobayashi, Jun, Murata, Isamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Short Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840435/
https://www.ncbi.nlm.nih.gov/pubmed/29512311
http://dx.doi.org/10.14814/phy2.13633
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author Kobayashi, Jun
Murata, Isamu
author_facet Kobayashi, Jun
Murata, Isamu
author_sort Kobayashi, Jun
collection PubMed
description Crush syndrome is characterized by ischemia/reperfusion injury (IRI). The protective effect of nitrite on experimentally induced IRI has been demonstrated in the heart, kidney, liver, and skeletal muscle. IRI in tissues and systemic organs occurs due to the massive generation of reactive oxygen species and subsequent systemic inflammation. Therefore, ischemic pre and postconditioning are performed in clinical practice. Intravenous administration of nitrite inhibits IRI through nitric oxide‐mediated mechanisms. In this paper, we discuss the utility of nitrite as a pharmacological postconditioning agent in the treatment of crush syndrome.
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spelling pubmed-58404352018-03-13 Nitrite as a pharmacological intervention for the successful treatment of crush syndrome Kobayashi, Jun Murata, Isamu Physiol Rep Short Reviews Crush syndrome is characterized by ischemia/reperfusion injury (IRI). The protective effect of nitrite on experimentally induced IRI has been demonstrated in the heart, kidney, liver, and skeletal muscle. IRI in tissues and systemic organs occurs due to the massive generation of reactive oxygen species and subsequent systemic inflammation. Therefore, ischemic pre and postconditioning are performed in clinical practice. Intravenous administration of nitrite inhibits IRI through nitric oxide‐mediated mechanisms. In this paper, we discuss the utility of nitrite as a pharmacological postconditioning agent in the treatment of crush syndrome. John Wiley and Sons Inc. 2018-03-07 /pmc/articles/PMC5840435/ /pubmed/29512311 http://dx.doi.org/10.14814/phy2.13633 Text en © 2018 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Reviews
Kobayashi, Jun
Murata, Isamu
Nitrite as a pharmacological intervention for the successful treatment of crush syndrome
title Nitrite as a pharmacological intervention for the successful treatment of crush syndrome
title_full Nitrite as a pharmacological intervention for the successful treatment of crush syndrome
title_fullStr Nitrite as a pharmacological intervention for the successful treatment of crush syndrome
title_full_unstemmed Nitrite as a pharmacological intervention for the successful treatment of crush syndrome
title_short Nitrite as a pharmacological intervention for the successful treatment of crush syndrome
title_sort nitrite as a pharmacological intervention for the successful treatment of crush syndrome
topic Short Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840435/
https://www.ncbi.nlm.nih.gov/pubmed/29512311
http://dx.doi.org/10.14814/phy2.13633
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