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Computed tomography morphologic features of pulmonary adenocarcinoma with brain/bone metastasis

BACKGROUND/AIMS: Brain and bone metastases are common in patients with lung cancer. The development of metastasis is associated with poor survival in lung cancer patients. Although tumor morphologic features on radiographs are routinely assessed for differentiation between benign and malignant lung...

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Autores principales: Hwang, Ki-Eun, Oh, Su-Jin, Park, Chul, Jeon, Se-Jeong, Lee, Jeong-Mi, Cha, Byong-Ki, Yoon, Kwon-Ha, Jeong, Eun-Taik, Kim, Hak-Ryul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Internal Medicine 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840592/
https://www.ncbi.nlm.nih.gov/pubmed/28192888
http://dx.doi.org/10.3904/kjim.2016.134
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author Hwang, Ki-Eun
Oh, Su-Jin
Park, Chul
Jeon, Se-Jeong
Lee, Jeong-Mi
Cha, Byong-Ki
Yoon, Kwon-Ha
Jeong, Eun-Taik
Kim, Hak-Ryul
author_facet Hwang, Ki-Eun
Oh, Su-Jin
Park, Chul
Jeon, Se-Jeong
Lee, Jeong-Mi
Cha, Byong-Ki
Yoon, Kwon-Ha
Jeong, Eun-Taik
Kim, Hak-Ryul
author_sort Hwang, Ki-Eun
collection PubMed
description BACKGROUND/AIMS: Brain and bone metastases are common in patients with lung cancer. The development of metastasis is associated with poor survival in lung cancer patients. Although tumor morphologic features on radiographs are routinely assessed for differentiation between benign and malignant lung nodules, they are not used to predict metastasis. We assessed morphologic features of pulmonary adenocarcinomas with brain/bone metastasis on computed tomography (CT) to identify related factors for metastasis. METHODS: We performed a retrospective analysis of initial chest CT findings (size, type of contour, percentage of necrosis, enhancement, presence or absence of calcification, and air cavity) from 2009 to 2010 of patients with brain or bone metastasis and compared the findings with those of patients without metastases. RESULTS: In total, 128 patients were included (78 men, 52 women; mean age 69 years; range, 36 to 87). Nineteen patients had brain metastases and 32 had bone metastases. Morphologic features associated with brain metastasis included size ≥ 50 mm (odds ratio [OR], 3.37; 95% confidence interval [CI], 1.24 to 9.17; p = 0.013), necrosis ≥ 30% (OR, 4.51; 95% CI, 1.62 to 12.55; p =0.002), and presence of calcification (OR, 3.97; 95% CI, 1.16 to 13.55; p = 0.035). Morphologic features associated with bone metastasis included necrosis ≥ 30% (OR, 4.639; 95% CI, 1.98 to 10.82; p < 0.001) and T 3 to 4 stage (OR, 2.53; 95% CI, 1.07 to 6.00; p = 0.031). CONCLUSIONS: We found that necrosis ≥ 30% was associated with pulmonary adenocarcinoma with brain and bone metastasis at initial chest CT morphologic feature. To validate these results, further research should be conducted.
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spelling pubmed-58405922018-03-08 Computed tomography morphologic features of pulmonary adenocarcinoma with brain/bone metastasis Hwang, Ki-Eun Oh, Su-Jin Park, Chul Jeon, Se-Jeong Lee, Jeong-Mi Cha, Byong-Ki Yoon, Kwon-Ha Jeong, Eun-Taik Kim, Hak-Ryul Korean J Intern Med Original Article BACKGROUND/AIMS: Brain and bone metastases are common in patients with lung cancer. The development of metastasis is associated with poor survival in lung cancer patients. Although tumor morphologic features on radiographs are routinely assessed for differentiation between benign and malignant lung nodules, they are not used to predict metastasis. We assessed morphologic features of pulmonary adenocarcinomas with brain/bone metastasis on computed tomography (CT) to identify related factors for metastasis. METHODS: We performed a retrospective analysis of initial chest CT findings (size, type of contour, percentage of necrosis, enhancement, presence or absence of calcification, and air cavity) from 2009 to 2010 of patients with brain or bone metastasis and compared the findings with those of patients without metastases. RESULTS: In total, 128 patients were included (78 men, 52 women; mean age 69 years; range, 36 to 87). Nineteen patients had brain metastases and 32 had bone metastases. Morphologic features associated with brain metastasis included size ≥ 50 mm (odds ratio [OR], 3.37; 95% confidence interval [CI], 1.24 to 9.17; p = 0.013), necrosis ≥ 30% (OR, 4.51; 95% CI, 1.62 to 12.55; p =0.002), and presence of calcification (OR, 3.97; 95% CI, 1.16 to 13.55; p = 0.035). Morphologic features associated with bone metastasis included necrosis ≥ 30% (OR, 4.639; 95% CI, 1.98 to 10.82; p < 0.001) and T 3 to 4 stage (OR, 2.53; 95% CI, 1.07 to 6.00; p = 0.031). CONCLUSIONS: We found that necrosis ≥ 30% was associated with pulmonary adenocarcinoma with brain and bone metastasis at initial chest CT morphologic feature. To validate these results, further research should be conducted. The Korean Association of Internal Medicine 2018-03 2016-02-15 /pmc/articles/PMC5840592/ /pubmed/28192888 http://dx.doi.org/10.3904/kjim.2016.134 Text en Copyright © 2018 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Hwang, Ki-Eun
Oh, Su-Jin
Park, Chul
Jeon, Se-Jeong
Lee, Jeong-Mi
Cha, Byong-Ki
Yoon, Kwon-Ha
Jeong, Eun-Taik
Kim, Hak-Ryul
Computed tomography morphologic features of pulmonary adenocarcinoma with brain/bone metastasis
title Computed tomography morphologic features of pulmonary adenocarcinoma with brain/bone metastasis
title_full Computed tomography morphologic features of pulmonary adenocarcinoma with brain/bone metastasis
title_fullStr Computed tomography morphologic features of pulmonary adenocarcinoma with brain/bone metastasis
title_full_unstemmed Computed tomography morphologic features of pulmonary adenocarcinoma with brain/bone metastasis
title_short Computed tomography morphologic features of pulmonary adenocarcinoma with brain/bone metastasis
title_sort computed tomography morphologic features of pulmonary adenocarcinoma with brain/bone metastasis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840592/
https://www.ncbi.nlm.nih.gov/pubmed/28192888
http://dx.doi.org/10.3904/kjim.2016.134
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