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Epidemiology and treatment of antimicrobialresistant gram-negative bacteria in Korea
Antimicrobial resistance is becoming one of the greatest challenges to public health worldwide. Infections by antimicrobial-resistant organisms could result in the failure of treatment, increased medical costs, prolonged hospital stays, and an increased socioeconomic burden. Antimicrobial usage in K...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Association of Internal Medicine
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840603/ https://www.ncbi.nlm.nih.gov/pubmed/29506343 http://dx.doi.org/10.3904/kjim.2018.028 |
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author | Kim, Young Ah Park, Yoon Soo |
author_facet | Kim, Young Ah Park, Yoon Soo |
author_sort | Kim, Young Ah |
collection | PubMed |
description | Antimicrobial resistance is becoming one of the greatest challenges to public health worldwide. Infections by antimicrobial-resistant organisms could result in the failure of treatment, increased medical costs, prolonged hospital stays, and an increased socioeconomic burden. Antimicrobial usage in Korea remains heavy, even after much effort to reduce their use. According to the Korean antimicrobial resistance surveillance system, the resistance rates of many bacteria are increasing. The resistance rate of Acinetobacter baumannii to imipenem in Korea increased to 85% in 2015, representing a major public threat. The reports of increased carbapenem resistance in Enterobacteriaceae are worrisome. More importantly, some carbapenem-resistant Enterobacteriaceae may result from the production of carbapenemases, which break down carbapenems. There are relatively few treatment options for extensively drug-resistant A. baumannii and carbapenem-resistant Enterobacteriaceae. Most reports are retrospective observational studies. Because there are little published data from randomized controlled trials, more data assessing antimicrobial treatment for extensively drug-resistant A. baumannii and carbapenem-resistant Enterobacteriaceae are needed to make treatment recommendations. |
format | Online Article Text |
id | pubmed-5840603 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | The Korean Association of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-58406032018-03-08 Epidemiology and treatment of antimicrobialresistant gram-negative bacteria in Korea Kim, Young Ah Park, Yoon Soo Korean J Intern Med Review Antimicrobial resistance is becoming one of the greatest challenges to public health worldwide. Infections by antimicrobial-resistant organisms could result in the failure of treatment, increased medical costs, prolonged hospital stays, and an increased socioeconomic burden. Antimicrobial usage in Korea remains heavy, even after much effort to reduce their use. According to the Korean antimicrobial resistance surveillance system, the resistance rates of many bacteria are increasing. The resistance rate of Acinetobacter baumannii to imipenem in Korea increased to 85% in 2015, representing a major public threat. The reports of increased carbapenem resistance in Enterobacteriaceae are worrisome. More importantly, some carbapenem-resistant Enterobacteriaceae may result from the production of carbapenemases, which break down carbapenems. There are relatively few treatment options for extensively drug-resistant A. baumannii and carbapenem-resistant Enterobacteriaceae. Most reports are retrospective observational studies. Because there are little published data from randomized controlled trials, more data assessing antimicrobial treatment for extensively drug-resistant A. baumannii and carbapenem-resistant Enterobacteriaceae are needed to make treatment recommendations. The Korean Association of Internal Medicine 2018-03 2018-02-27 /pmc/articles/PMC5840603/ /pubmed/29506343 http://dx.doi.org/10.3904/kjim.2018.028 Text en Copyright © 2018 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Kim, Young Ah Park, Yoon Soo Epidemiology and treatment of antimicrobialresistant gram-negative bacteria in Korea |
title | Epidemiology and treatment of antimicrobialresistant gram-negative bacteria in Korea |
title_full | Epidemiology and treatment of antimicrobialresistant gram-negative bacteria in Korea |
title_fullStr | Epidemiology and treatment of antimicrobialresistant gram-negative bacteria in Korea |
title_full_unstemmed | Epidemiology and treatment of antimicrobialresistant gram-negative bacteria in Korea |
title_short | Epidemiology and treatment of antimicrobialresistant gram-negative bacteria in Korea |
title_sort | epidemiology and treatment of antimicrobialresistant gram-negative bacteria in korea |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840603/ https://www.ncbi.nlm.nih.gov/pubmed/29506343 http://dx.doi.org/10.3904/kjim.2018.028 |
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