NFAT control of immune function: New Frontiers for an Abiding Trooper

Nuclear factor of activated T cells (NFAT) was first described almost three decades ago as a Ca (2+)/calcineurin-regulated transcription factor in T cells. Since then, a large body of research uncovered the regulation and physiological function of different NFAT homologues in the immune system and m...

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Detalles Bibliográficos
Autores principales: Vaeth, Martin, Feske, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840618/
https://www.ncbi.nlm.nih.gov/pubmed/29568499
http://dx.doi.org/10.12688/f1000research.13426.1
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author Vaeth, Martin
Feske, Stefan
author_facet Vaeth, Martin
Feske, Stefan
author_sort Vaeth, Martin
collection PubMed
description Nuclear factor of activated T cells (NFAT) was first described almost three decades ago as a Ca (2+)/calcineurin-regulated transcription factor in T cells. Since then, a large body of research uncovered the regulation and physiological function of different NFAT homologues in the immune system and many other tissues. In this review, we will discuss novel roles of NFAT in T cells, focusing mainly on its function in humoral immune responses, immunological tolerance, and the regulation of immune metabolism.
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spelling pubmed-58406182018-03-21 NFAT control of immune function: New Frontiers for an Abiding Trooper Vaeth, Martin Feske, Stefan F1000Res Review Nuclear factor of activated T cells (NFAT) was first described almost three decades ago as a Ca (2+)/calcineurin-regulated transcription factor in T cells. Since then, a large body of research uncovered the regulation and physiological function of different NFAT homologues in the immune system and many other tissues. In this review, we will discuss novel roles of NFAT in T cells, focusing mainly on its function in humoral immune responses, immunological tolerance, and the regulation of immune metabolism. F1000 Research Limited 2018-03-02 /pmc/articles/PMC5840618/ /pubmed/29568499 http://dx.doi.org/10.12688/f1000research.13426.1 Text en Copyright: © 2018 Vaeth M and Feske S http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Vaeth, Martin
Feske, Stefan
NFAT control of immune function: New Frontiers for an Abiding Trooper
title NFAT control of immune function: New Frontiers for an Abiding Trooper
title_full NFAT control of immune function: New Frontiers for an Abiding Trooper
title_fullStr NFAT control of immune function: New Frontiers for an Abiding Trooper
title_full_unstemmed NFAT control of immune function: New Frontiers for an Abiding Trooper
title_short NFAT control of immune function: New Frontiers for an Abiding Trooper
title_sort nfat control of immune function: new frontiers for an abiding trooper
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840618/
https://www.ncbi.nlm.nih.gov/pubmed/29568499
http://dx.doi.org/10.12688/f1000research.13426.1
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