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Expression of pAkt is associated with a poor prognosis in Chinese women with invasive ductal breast cancer

Over the past three decades, numerous patients with breast cancer succumbed to cancer metastasis and recurrence, while, the exact mechanisms underlying this malignancy, and the potential biomarkers for prognosis prediction remain elusive. It was previously demonstrated that phosphorylated RAC-α seri...

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Autores principales: Zhou, Ling, Wang, Min, Guo, Chongyong, Zhu, Ying, Yu, Hua, Zhang, Lu, Yu, Pei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840663/
https://www.ncbi.nlm.nih.gov/pubmed/29552125
http://dx.doi.org/10.3892/ol.2018.7965
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author Zhou, Ling
Wang, Min
Guo, Chongyong
Zhu, Ying
Yu, Hua
Zhang, Lu
Yu, Pei
author_facet Zhou, Ling
Wang, Min
Guo, Chongyong
Zhu, Ying
Yu, Hua
Zhang, Lu
Yu, Pei
author_sort Zhou, Ling
collection PubMed
description Over the past three decades, numerous patients with breast cancer succumbed to cancer metastasis and recurrence, while, the exact mechanisms underlying this malignancy, and the potential biomarkers for prognosis prediction remain elusive. It was previously demonstrated that phosphorylated RAC-α serine/threonine-protein kinase (pAkt) and Beclin 1 was associated with cancer metastasis, and recurrence. Thus far, the expression patterns of pAkt and Beclin 1 in breast cancer tissues, and their associations with the prognosis of invasive ductal breast cancer remain inconclusive, which may be due to various factors, including ethnicity and pathological types. In the present study, a total of 90 Chinese female patients with invasive ductal breast cancer between June 1999 and August 2002 were enrolled at Shanghai First People's Hospital (Shanghai, China). The patients were followed up from 5 months to 13.5 years for survival analysis. The expressional levels of pAkt and Beclin 1 in invasive ductal breast cancer tissues, and the normal paracancerous tissues were measured by immunohistochemistry. Associations with prognosis following surgery were further evaluated using Cox regression analysis. In 90 invasive ductal breast cancer samples, pAkt was detected in 17 (18.9%) samples and Beclin 1 in 33 (36.7%) samples, but both were not detected in any of the paracancerous samples. Survival analysis revealed that pAkt expression carried a tendency to predict a shorter disease-free survival (DFS) in patients with invasive ductal breast cancer. Additionally, Beclin 1 expression was not significantly associated with survival. Furthermore, univariate Cox regression analysis demonstrated that pAkt expression was negatively associated with DFS and overall survival. Multivariate Cox regression analysis indicated that pAkt expression was an independent risk factor associated with poor prognosis in patients with invasive ductal breast cancer (all P<0.05). pAkt may be used as a potential prognostic biomarker in Chinese women with invasive ductal breast cancer.
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spelling pubmed-58406632018-03-16 Expression of pAkt is associated with a poor prognosis in Chinese women with invasive ductal breast cancer Zhou, Ling Wang, Min Guo, Chongyong Zhu, Ying Yu, Hua Zhang, Lu Yu, Pei Oncol Lett Articles Over the past three decades, numerous patients with breast cancer succumbed to cancer metastasis and recurrence, while, the exact mechanisms underlying this malignancy, and the potential biomarkers for prognosis prediction remain elusive. It was previously demonstrated that phosphorylated RAC-α serine/threonine-protein kinase (pAkt) and Beclin 1 was associated with cancer metastasis, and recurrence. Thus far, the expression patterns of pAkt and Beclin 1 in breast cancer tissues, and their associations with the prognosis of invasive ductal breast cancer remain inconclusive, which may be due to various factors, including ethnicity and pathological types. In the present study, a total of 90 Chinese female patients with invasive ductal breast cancer between June 1999 and August 2002 were enrolled at Shanghai First People's Hospital (Shanghai, China). The patients were followed up from 5 months to 13.5 years for survival analysis. The expressional levels of pAkt and Beclin 1 in invasive ductal breast cancer tissues, and the normal paracancerous tissues were measured by immunohistochemistry. Associations with prognosis following surgery were further evaluated using Cox regression analysis. In 90 invasive ductal breast cancer samples, pAkt was detected in 17 (18.9%) samples and Beclin 1 in 33 (36.7%) samples, but both were not detected in any of the paracancerous samples. Survival analysis revealed that pAkt expression carried a tendency to predict a shorter disease-free survival (DFS) in patients with invasive ductal breast cancer. Additionally, Beclin 1 expression was not significantly associated with survival. Furthermore, univariate Cox regression analysis demonstrated that pAkt expression was negatively associated with DFS and overall survival. Multivariate Cox regression analysis indicated that pAkt expression was an independent risk factor associated with poor prognosis in patients with invasive ductal breast cancer (all P<0.05). pAkt may be used as a potential prognostic biomarker in Chinese women with invasive ductal breast cancer. D.A. Spandidos 2018-04 2018-02-06 /pmc/articles/PMC5840663/ /pubmed/29552125 http://dx.doi.org/10.3892/ol.2018.7965 Text en Copyright: © Zhou et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Zhou, Ling
Wang, Min
Guo, Chongyong
Zhu, Ying
Yu, Hua
Zhang, Lu
Yu, Pei
Expression of pAkt is associated with a poor prognosis in Chinese women with invasive ductal breast cancer
title Expression of pAkt is associated with a poor prognosis in Chinese women with invasive ductal breast cancer
title_full Expression of pAkt is associated with a poor prognosis in Chinese women with invasive ductal breast cancer
title_fullStr Expression of pAkt is associated with a poor prognosis in Chinese women with invasive ductal breast cancer
title_full_unstemmed Expression of pAkt is associated with a poor prognosis in Chinese women with invasive ductal breast cancer
title_short Expression of pAkt is associated with a poor prognosis in Chinese women with invasive ductal breast cancer
title_sort expression of pakt is associated with a poor prognosis in chinese women with invasive ductal breast cancer
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840663/
https://www.ncbi.nlm.nih.gov/pubmed/29552125
http://dx.doi.org/10.3892/ol.2018.7965
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