Cargando…

Safety, tolerability and efficacy of intra-articular Progenza in knee osteoarthritis: a randomized double-blind placebo-controlled single ascending dose study

BACKGROUND: Cell therapies are being investigated as potential disease modifying treatment options for osteoarthritis (OA). Progenza (PRG) comprises in vitro expanded mesenchymal stem cells derived from human donor adipose tissue combined with cell culture supernatant. The primary objective of this...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kuah, D., Sivell, S., Longworth, T., James, K., Guermazi, A., Cicuttini, F., Wang, Y., Craig, S., Comin, G., Robinson, D., Wilson, J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840781/ https://www.ncbi.nlm.nih.gov/pubmed/29510712 http://dx.doi.org/10.1186/s12967-018-1420-z

Ejemplares similares

Comparison between intra-articular ozone and placebo in the treatment of knee osteoarthritis: A randomized, double-blinded, placebo-controlled study
por: Lopes de Jesus, Carlos César, et al.
Publicado: (2017)

Use of intra-articular hyaluronic acid in knee osteoarthritis or osteoarthritis
por: Anhesini, Mauricio, et al.
Publicado: (2023)

Intra-articular placebo effect in the treatment of knee osteoarthritis: a survey of the current clinical evidence
por: Fazeli, Mir Sohail, et al.
Publicado: (2022)

Cartilage turnover and intra-articular corticosteroid injections in knee osteoarthritis
por: Klocke, Rainer, et al.
Publicado: (2018)

Intra-articular hyaluronans: the treatment of knee pain in osteoarthritis
por: Goldberg, Victor M, et al.
Publicado: (2010)

Radiographically detectable intra-articular mineralization: Predictor of knee osteoarthritis outcomes or only an indicator of aging? A brief report from the osteoarthritis initiative
por: Ibad, Hamza Ahmed, et al.
Publicado: (2023)

Intra-Articular Injections in Knee Osteoarthritis: A Review of Literature
por: Testa, Gianluca, et al.
Publicado: (2021)

Are intra-articular injections in the treatment of knee osteoarthritis effective enough?
por: Atik, O. Şahap, et al.
Publicado: (2022)

Structural effects of intra-articular TGF-β1 in moderate to advanced knee osteoarthritis: MRI-based assessment in a randomized controlled trial
por: Guermazi, A., et al.
Publicado: (2017)

Structural predictors of response to intra-articular steroid injection in symptomatic knee osteoarthritis
por: Maricar, Nasimah, et al.
Publicado: (2017)

Comparison of efficacy of intra-articular morphine and steroid in patients with knee osteoarthritis
por: Beyaz, Serbülent Gökhan
Publicado: (2012)

Efficacy and predictive factors of response to intra-articular corticosteroids in knee osteoarthritis
por: Heidari, Parnaz, et al.
Publicado: (2020)

The Effect of Platelet-Rich Plasma on the Intra-Articular Microenvironment in Knee Osteoarthritis
por: Szwedowski, Dawid, et al.
Publicado: (2021)

A Randomized Trial of Intra-articular Injection Therapy for Knee Osteoarthritis
por: Tschopp, Marcel, et al.
Publicado: (2023)

Single, intra-articular treatment with 6 ml hylan G-F 20 in patients with symptomatic primary osteoarthritis of the knee: a randomised, multicentre, double-blind, placebo controlled trial
por: Chevalier, X, et al.
Publicado: (2009)

Effects of laterally wedged insoles on symptoms and disease progression in medial knee osteoarthritis: a protocol for a randomised, double-blind, placebo controlled trial
por: Bennell, Kim, et al.
Publicado: (2007)

Arthroscopy Association of Canada Position Statement on Intra-articular Injections for Knee Osteoarthritis
por: Kopka, Michaela, et al.
Publicado: (2019)

Cost-Effectiveness of Different Forms of Intra-Articular Injections for the Treatment of Osteoarthritis of the Knee
por: Rosen, Jeffrey, et al.
Publicado: (2016)

Biocompatibility study of different hyaluronan products for intra-articular treatment of knee osteoarthritis
por: Yoshioka, Keiji, et al.
Publicado: (2019)

Intra-Articular Injection of PRP in the Treatment of Knee Osteoarthritis Using Big Data
por: Lin, Zhijin, et al.
Publicado: (2021)

Knee Osteoarthritis Therapy: Recent Advances in Intra-Articular Drug Delivery Systems
por: Ma, Luoyang, et al.
Publicado: (2022)

Acupotomy combined with intra-articular injection of sodium hyaluronate in the treatment of knee osteoarthritis
por: Chai, Ya-peng, et al.
Publicado: (2022)

Effects of a Single Intra-Articular Injection of a Microsphere Formulation of Triamcinolone Acetonide on Knee Osteoarthritis Pain: A Double-Blinded, Randomized, Placebo-Controlled, Multinational Study
por: Conaghan, Philip G., et al.
Publicado: (2018)

Intra-articular autologous conditioned serum and triamcinolone injections in patients with knee osteoarthritis: a controlled, randomized, double-blind study
por: Damjanov, Nemanja, et al.
Publicado: (2023)

Severe Acute Localized Reactions Following Intra-Articular Hyaluronic Acid Injections in Knee Osteoarthritis
por: Ong, Kevin L., et al.
Publicado: (2020)

Intra-Articular Hyaluronic Acid as Treatment in Elderly and Middle-Aged Patients with Knee Osteoarthritis
por: Uçar, Demet, et al.
Publicado: (2013)

Predictors of response to intra-articular steroid injections in knee osteoarthritis—a systematic review
por: Maricar, Nasimah, et al.
Publicado: (2013)

Intra-articular hyaluronic acid and corticosteroids in the treatment of knee osteoarthritis: A meta-analysis
por: WANG, FANG, et al.
Publicado: (2015)

Early Efficacy of Intra-Articular HYADD® 4 (Hymovis®) Injections for Symptomatic Knee Osteoarthritis
por: Priano, Ferdinando
Publicado: (2017)

Effectiveness of intra-articular ozone injections on outcomes of post-arthroscopic surgery for knee osteoarthritis
por: Wang, Xiangjiang, et al.
Publicado: (2018)

Mesenchymal stromal cell products for intra-articular knee injections for conservative management of osteoarthritis
por: Andia, Isabel, et al.
Publicado: (2021)

Intra-Articular Administration of Cramp into Mouse Knee Joint Exacerbates Experimental Osteoarthritis Progression
por: Choi, Moon-Chang, et al.
Publicado: (2021)

Therapeutic Effects of Intra-articular Botulinum Neurotoxin Versus Physical Therapy in Knee Osteoarthritis
por: Rezasoltani, Zahra, et al.
Publicado: (2021)

Cytokine Profiling and Intra-Articular Injection of Autologous Platelet-Rich Plasma in Knee Osteoarthritis
por: Riewruja, Kanyakorn, et al.
Publicado: (2022)

Comparing the efficacy of different intra-articular injections for knee osteoarthritis: A network analysis
por: Lin, Xingzhen, et al.
Publicado: (2022)

Intra-Articular Mesenchymal Stem Cell Injection for Knee Osteoarthritis: Mechanisms and Clinical Evidence
por: Wei, Pengxu, et al.
Publicado: (2022)

Retracted: Intra-Articular Injection of PRP in the Treatment of Knee Osteoarthritis Using Big Data
por: Healthcare Engineering, Journal of
Publicado: (2023)

Efficacy of intra-articular injections of platelet-rich plasma as a symptom- and disease-modifying treatment for knee osteoarthritis - the RESTORE trial protocol
por: Paterson, Kade L., et al.
Publicado: (2018)

Intra-articular injections of sodium hyaluronate (Hyalgan(®)) in osteoarthritis of the knee. a randomized, controlled, double-blind, multicenter trial in the asian population
por: Huang, Teng-Le, et al.
Publicado: (2011)

Effectiveness of intra-articular injections of sodium bicarbonate and calcium gluconate in the treatment of osteoarthritis of the knee: a randomized double-blind clinical trial
por: García-Padilla, Sandra, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_jat182citrmg9nq288qq1282ll