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SABRE-Relay: A Versatile Route to Hyperpolarization

[Image: see text] Signal Amplification by Reversible Exchange (SABRE) is used to switch on the latent singlet spin order of para-hydrogen (p-H(2)) so that it can hyperpolarize a substrate (sub = nicotinamide, nicotinate, niacin, pyrimidine, and pyrazine). The substrate then reacts reversibly with [P...

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Autores principales: Roy, Soumya S., Appleby, Kate M., Fear, Elizabeth J., Duckett, Simon B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840861/
https://www.ncbi.nlm.nih.gov/pubmed/29432020
http://dx.doi.org/10.1021/acs.jpclett.7b03026
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author Roy, Soumya S.
Appleby, Kate M.
Fear, Elizabeth J.
Duckett, Simon B.
author_facet Roy, Soumya S.
Appleby, Kate M.
Fear, Elizabeth J.
Duckett, Simon B.
author_sort Roy, Soumya S.
collection PubMed
description [Image: see text] Signal Amplification by Reversible Exchange (SABRE) is used to switch on the latent singlet spin order of para-hydrogen (p-H(2)) so that it can hyperpolarize a substrate (sub = nicotinamide, nicotinate, niacin, pyrimidine, and pyrazine). The substrate then reacts reversibly with [Pt(OTf)(2)(bis-diphenylphosphinopropane)] by displacing OTf(–) to form [Pt(OTf)(sub)(bis-diphenylphosphinopropane)]OTf. The (31)P NMR signals of these metal complexes prove to be enhanced when the substrate possesses an accessible singlet state or long-lived Zeeman polarization. In the case of pyrazine, the corresponding (31)P signal was 105 ± 8 times larger than expected, which equated to an 8 h reduction in total scan time for an equivalent signal-to-noise ratio under normal acquisition conditions. Hence, p-H(2) derived spin order is successfully relayed into a second metal complex via a suitable polarization carrier (sub). When fully developed, we expect this route involving a second catalyst to successfully hyperpolarize many classes of substrates that are not amenable to the original SABRE method.
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spelling pubmed-58408612018-03-12 SABRE-Relay: A Versatile Route to Hyperpolarization Roy, Soumya S. Appleby, Kate M. Fear, Elizabeth J. Duckett, Simon B. J Phys Chem Lett [Image: see text] Signal Amplification by Reversible Exchange (SABRE) is used to switch on the latent singlet spin order of para-hydrogen (p-H(2)) so that it can hyperpolarize a substrate (sub = nicotinamide, nicotinate, niacin, pyrimidine, and pyrazine). The substrate then reacts reversibly with [Pt(OTf)(2)(bis-diphenylphosphinopropane)] by displacing OTf(–) to form [Pt(OTf)(sub)(bis-diphenylphosphinopropane)]OTf. The (31)P NMR signals of these metal complexes prove to be enhanced when the substrate possesses an accessible singlet state or long-lived Zeeman polarization. In the case of pyrazine, the corresponding (31)P signal was 105 ± 8 times larger than expected, which equated to an 8 h reduction in total scan time for an equivalent signal-to-noise ratio under normal acquisition conditions. Hence, p-H(2) derived spin order is successfully relayed into a second metal complex via a suitable polarization carrier (sub). When fully developed, we expect this route involving a second catalyst to successfully hyperpolarize many classes of substrates that are not amenable to the original SABRE method. American Chemical Society 2018-02-12 2018-03-01 /pmc/articles/PMC5840861/ /pubmed/29432020 http://dx.doi.org/10.1021/acs.jpclett.7b03026 Text en Copyright © 2018 American Chemical Society This is an open access article published under a Creative Commons Attribution (CC-BY) License (http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html) , which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
spellingShingle Roy, Soumya S.
Appleby, Kate M.
Fear, Elizabeth J.
Duckett, Simon B.
SABRE-Relay: A Versatile Route to Hyperpolarization
title SABRE-Relay: A Versatile Route to Hyperpolarization
title_full SABRE-Relay: A Versatile Route to Hyperpolarization
title_fullStr SABRE-Relay: A Versatile Route to Hyperpolarization
title_full_unstemmed SABRE-Relay: A Versatile Route to Hyperpolarization
title_short SABRE-Relay: A Versatile Route to Hyperpolarization
title_sort sabre-relay: a versatile route to hyperpolarization
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840861/
https://www.ncbi.nlm.nih.gov/pubmed/29432020
http://dx.doi.org/10.1021/acs.jpclett.7b03026
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