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Glibenclamide exacerbates adriamycin-induced cardiotoxicity by activating oxidative stress-induced endoplasmic reticulum stress in rats

Adriamycin (ADR) is a chemotherapeutic drug used to treat tumors in a clinical setting. However, its use is limited by a side effect of cardiotoxicity. Glibenclamide (Gli), an inhibitor of mitochondrial ATP-dependent potassium (K-ATP) channels, blocks the cardioprotective effects of mitochondrial K-...

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Detalles Bibliográficos
Autores principales:	Liu, Meng-Lin, Wang, Meng-Long, Lv, Jing-Jun, Wei, Jie, Wan, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840948/ https://www.ncbi.nlm.nih.gov/pubmed/29545864 http://dx.doi.org/10.3892/etm.2018.5862

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