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PTEN knockdown with the Y444F mutant AAV2 vector promotes axonal regeneration in the adult optic nerve
The lack of axonal regeneration is the major cause of vision loss after optic nerve injury in adult mammals. Activating the PI3K/AKT/mTOR signaling pathway has been shown to enhance the intrinsic growth capacity of neurons and to facilitate axonal regeneration in the central nervous system after inj...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Medknow Publications & Media Pvt Ltd
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840979/ https://www.ncbi.nlm.nih.gov/pubmed/29451218 http://dx.doi.org/10.4103/1673-5374.224381 |