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The Effect of Pregabalin and Metformin on Subacute and Chronic Radiculopathy
BACKGROUND: Radicular pain is one of the most common forms of chronic pain in the world, which has challenges about effective medical therapy. The aim of this study was to evaluate the effect of pregabalin (PGB) and metformin (Met) on subacute and chronic radiculopathy. MATERIALS AND METHODS: This d...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841011/ https://www.ncbi.nlm.nih.gov/pubmed/29531924 http://dx.doi.org/10.4103/2277-9175.225599 |
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author | Ansari, Behnaz Ghasemi, Majid Ahmadian, Mana Khorvash, Fariborz |
author_facet | Ansari, Behnaz Ghasemi, Majid Ahmadian, Mana Khorvash, Fariborz |
author_sort | Ansari, Behnaz |
collection | PubMed |
description | BACKGROUND: Radicular pain is one of the most common forms of chronic pain in the world, which has challenges about effective medical therapy. The aim of this study was to evaluate the effect of pregabalin (PGB) and metformin (Met) on subacute and chronic radiculopathy. MATERIALS AND METHODS: This double-blind prospective clinical trial was performed on 71 patients with subacute and chronic cervical and lumbosacral radiculopathy. Group A was treated with PGB 75 mg daily while Group B was treated with PGB 75 mg daily and Met 500 mg daily for 3 months. Finally, the pain score in both groups was evaluated based on visual analog scale (VAS) and numerical scale pain. RESULTS: The results showed a significant reduction in VAS and pain severity in both groups but this reduction in the terms of VAS (47.79% vs. 46.48%, P = 0.125) and pain severity (47.1% vs. 39.2%, P = 0.264) was more in treated patients with PGB and Met as compared to PGB group while total pain experience (53.5% vs. 49.1%, P = 0.464) and interference with daily function (57.1% vs. 50.61%, P = 0.726) were more in patients treated with PGB alone. CONCLUSION: Our results showed that PGB and PGB + Met reduced pain intensity and interference with daily function while we did not observe significant differences between two groups. PGB alone would have the potentiality to become a simple and economic means to decrease radicular pain. |
format | Online Article Text |
id | pubmed-5841011 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-58410112018-03-12 The Effect of Pregabalin and Metformin on Subacute and Chronic Radiculopathy Ansari, Behnaz Ghasemi, Majid Ahmadian, Mana Khorvash, Fariborz Adv Biomed Res Original Article BACKGROUND: Radicular pain is one of the most common forms of chronic pain in the world, which has challenges about effective medical therapy. The aim of this study was to evaluate the effect of pregabalin (PGB) and metformin (Met) on subacute and chronic radiculopathy. MATERIALS AND METHODS: This double-blind prospective clinical trial was performed on 71 patients with subacute and chronic cervical and lumbosacral radiculopathy. Group A was treated with PGB 75 mg daily while Group B was treated with PGB 75 mg daily and Met 500 mg daily for 3 months. Finally, the pain score in both groups was evaluated based on visual analog scale (VAS) and numerical scale pain. RESULTS: The results showed a significant reduction in VAS and pain severity in both groups but this reduction in the terms of VAS (47.79% vs. 46.48%, P = 0.125) and pain severity (47.1% vs. 39.2%, P = 0.264) was more in treated patients with PGB and Met as compared to PGB group while total pain experience (53.5% vs. 49.1%, P = 0.464) and interference with daily function (57.1% vs. 50.61%, P = 0.726) were more in patients treated with PGB alone. CONCLUSION: Our results showed that PGB and PGB + Met reduced pain intensity and interference with daily function while we did not observe significant differences between two groups. PGB alone would have the potentiality to become a simple and economic means to decrease radicular pain. Medknow Publications & Media Pvt Ltd 2018-02-16 /pmc/articles/PMC5841011/ /pubmed/29531924 http://dx.doi.org/10.4103/2277-9175.225599 Text en Copyright: © 2018 Advanced Biomedical Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Ansari, Behnaz Ghasemi, Majid Ahmadian, Mana Khorvash, Fariborz The Effect of Pregabalin and Metformin on Subacute and Chronic Radiculopathy |
title | The Effect of Pregabalin and Metformin on Subacute and Chronic Radiculopathy |
title_full | The Effect of Pregabalin and Metformin on Subacute and Chronic Radiculopathy |
title_fullStr | The Effect of Pregabalin and Metformin on Subacute and Chronic Radiculopathy |
title_full_unstemmed | The Effect of Pregabalin and Metformin on Subacute and Chronic Radiculopathy |
title_short | The Effect of Pregabalin and Metformin on Subacute and Chronic Radiculopathy |
title_sort | effect of pregabalin and metformin on subacute and chronic radiculopathy |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841011/ https://www.ncbi.nlm.nih.gov/pubmed/29531924 http://dx.doi.org/10.4103/2277-9175.225599 |
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