Inhibition of the Hexosamine Biosynthetic Pathway by targeting PGM3 causes breast cancer growth arrest and apoptosis

Cancer aberrant N- and O-linked protein glycosylation, frequently resulting from an augmented flux through the Hexosamine Biosynthetic Pathway (HBP), play different roles in tumor progression. However, the low specificity and toxicity of the existing HBP inhibitors prevented their use for cancer tre...

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Detalles Bibliográficos
Autores principales: Ricciardiello, Francesca, Votta, Giuseppina, Palorini, Roberta, Raccagni, Isabella, Brunelli, Laura, Paiotta, Alice, Tinelli, Francesca, D’Orazio, Giuseppe, Valtorta, Silvia, De Gioia, Luca, Pastorelli, Roberta, Moresco, Rosa Maria, La Ferla, Barbara, Chiaradonna, Ferdinando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841296/
https://www.ncbi.nlm.nih.gov/pubmed/29515119
http://dx.doi.org/10.1038/s41419-018-0405-4

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