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Pan-class I PI3-kinase inhibitor BKM120 induces MEK1/2-dependent mitotic catastrophe in non-Hodgkin lymphoma leading to apoptosis or polyploidy determined by Bax/Bak and p53

Constitutive signaling of PI3K/Akt/mTOR plays a prominent role in malignant transformation and progression of B-cell non-Hodgkin lymphomas (B-NHL) underscoring the need for PI3K targeted therapies. The pan-class I PI3-kinase inhibitor BKM120 has shown preclinical activity in distinct malignancies an...

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Detalles Bibliográficos
Autores principales:	Müller, Anja, Gillissen, Bernd, Richter, Antje, Richter, Anja, Chumduri, Cindrilla, Daniel, Peter T., Scholz, Christian W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841308/ https://www.ncbi.nlm.nih.gov/pubmed/29515122 http://dx.doi.org/10.1038/s41419-018-0413-4

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