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NF-κB inhibition by dimethylaminoparthenolide radiosensitizes non-small-cell lung carcinoma by blocking DNA double-strand break repair

Despite optimal chemotherapy, radiotherapy (RT), and/or surgery, non-small-cell lung carcinoma (NSCLC) remains the leading cause of cancer-related death in the US and worldwide. Thoracic RT, a mainstay in the treatment of locally advanced NSCLC, is often restricted in efficacy by a therapeutic index...

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Detalles Bibliográficos
Autores principales: Deraska, Peter V., O’Leary, Colin, Reavis, Hunter D., Labe, Shelby, Dinh, Tru-Khang, Lazaro, Jean-Bernard, Sweeney, Christopher, D’Andrea, Alan D., Kozono, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841323/
https://www.ncbi.nlm.nih.gov/pubmed/29531807
http://dx.doi.org/10.1038/s41420-017-0008-3