Cargando…

Effects of degree of pulmonary fissure completeness on major in-hospital outcomes after video-assisted thoracoscopic lung cancer lobectomy: a retrospective-cohort study

BACKGROUND: To evaluate the clinical significance of degree of pulmonary fissure completeness (PFC) on major in-hospital outcomes following video-assisted thoracoscopic (VATS) lobectomy for non-small-cell lung cancer (NSCLC). MATERIALS AND METHODS: We carried out a single-center retrospective analys...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Shuangjiang, Wang, Zhiqiang, Zhou, Kun, Wang, Yan, Wu, Yanming, Li, Pengfei, Che, Guowei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841327/
https://www.ncbi.nlm.nih.gov/pubmed/29535528
http://dx.doi.org/10.2147/TCRM.S159632
_version_ 1783304730245595136
author Li, Shuangjiang
Wang, Zhiqiang
Zhou, Kun
Wang, Yan
Wu, Yanming
Li, Pengfei
Che, Guowei
author_facet Li, Shuangjiang
Wang, Zhiqiang
Zhou, Kun
Wang, Yan
Wu, Yanming
Li, Pengfei
Che, Guowei
author_sort Li, Shuangjiang
collection PubMed
description BACKGROUND: To evaluate the clinical significance of degree of pulmonary fissure completeness (PFC) on major in-hospital outcomes following video-assisted thoracoscopic (VATS) lobectomy for non-small-cell lung cancer (NSCLC). MATERIALS AND METHODS: We carried out a single-center retrospective analysis on the prospectively maintained database at our unit between August 2014 and October 2015. Patients were divided into two groups based on their fissure sum average (FSA). Patients with FSA >1 (1< FSA ≤3) were considered to have incomplete pulmonary fissures (group A), while patients with FSA of 0–1 were considered to have complete pulmonary fissures (group B). Demographic differences in perioperative characteristics and surgical outcomes between these two groups were initially assessed. Then, a multivariate logistic-regression analysis was further conducted to identify the independent predictors for major in-hospital outcomes. RESULTS: A total of 563 patients undergoing VATS lobectomy for NSCLC were enrolled. There were 190 patients in group A and 373 patients in group B. The overall morbidity and mortality rates of our cohort were 30.6% and 0.5%, respectively. Group A patients had a significantly higher overall morbidity rate than group B patients (42.1% vs 24.7%, P<0.001). Both minor morbidity (40.5% vs 22%, P<0.001) and major morbidity (11.1% vs 5.6%, P=0.021) rates in group A patients were also significantly higher than group B patients. No significant difference was observed in mortality rate between these two groups (1.1% vs 0.3%, P=0.26). The incomplete degree of PFC was significantly correlated with length of stay and chest-tube duration (log-rank P<0.001) after surgery. Finally, the incomplete degree of PFC was found to be predictive of overall morbidity (OR 2.08, P<0.001), minor morbidity (OR 2.39, P<0.001), and major morbidity (OR 2.06, P=0.031) by multivariate logistic-regression analyses. CONCLUSION: Degree of PFC is an excellent categorical predictor for both major and minor morbidity after VATS lobectomy for NSCLC.
format Online
Article
Text
id pubmed-5841327
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-58413272018-03-13 Effects of degree of pulmonary fissure completeness on major in-hospital outcomes after video-assisted thoracoscopic lung cancer lobectomy: a retrospective-cohort study Li, Shuangjiang Wang, Zhiqiang Zhou, Kun Wang, Yan Wu, Yanming Li, Pengfei Che, Guowei Ther Clin Risk Manag Original Research BACKGROUND: To evaluate the clinical significance of degree of pulmonary fissure completeness (PFC) on major in-hospital outcomes following video-assisted thoracoscopic (VATS) lobectomy for non-small-cell lung cancer (NSCLC). MATERIALS AND METHODS: We carried out a single-center retrospective analysis on the prospectively maintained database at our unit between August 2014 and October 2015. Patients were divided into two groups based on their fissure sum average (FSA). Patients with FSA >1 (1< FSA ≤3) were considered to have incomplete pulmonary fissures (group A), while patients with FSA of 0–1 were considered to have complete pulmonary fissures (group B). Demographic differences in perioperative characteristics and surgical outcomes between these two groups were initially assessed. Then, a multivariate logistic-regression analysis was further conducted to identify the independent predictors for major in-hospital outcomes. RESULTS: A total of 563 patients undergoing VATS lobectomy for NSCLC were enrolled. There were 190 patients in group A and 373 patients in group B. The overall morbidity and mortality rates of our cohort were 30.6% and 0.5%, respectively. Group A patients had a significantly higher overall morbidity rate than group B patients (42.1% vs 24.7%, P<0.001). Both minor morbidity (40.5% vs 22%, P<0.001) and major morbidity (11.1% vs 5.6%, P=0.021) rates in group A patients were also significantly higher than group B patients. No significant difference was observed in mortality rate between these two groups (1.1% vs 0.3%, P=0.26). The incomplete degree of PFC was significantly correlated with length of stay and chest-tube duration (log-rank P<0.001) after surgery. Finally, the incomplete degree of PFC was found to be predictive of overall morbidity (OR 2.08, P<0.001), minor morbidity (OR 2.39, P<0.001), and major morbidity (OR 2.06, P=0.031) by multivariate logistic-regression analyses. CONCLUSION: Degree of PFC is an excellent categorical predictor for both major and minor morbidity after VATS lobectomy for NSCLC. Dove Medical Press 2018-03-02 /pmc/articles/PMC5841327/ /pubmed/29535528 http://dx.doi.org/10.2147/TCRM.S159632 Text en © 2018 Li et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Li, Shuangjiang
Wang, Zhiqiang
Zhou, Kun
Wang, Yan
Wu, Yanming
Li, Pengfei
Che, Guowei
Effects of degree of pulmonary fissure completeness on major in-hospital outcomes after video-assisted thoracoscopic lung cancer lobectomy: a retrospective-cohort study
title Effects of degree of pulmonary fissure completeness on major in-hospital outcomes after video-assisted thoracoscopic lung cancer lobectomy: a retrospective-cohort study
title_full Effects of degree of pulmonary fissure completeness on major in-hospital outcomes after video-assisted thoracoscopic lung cancer lobectomy: a retrospective-cohort study
title_fullStr Effects of degree of pulmonary fissure completeness on major in-hospital outcomes after video-assisted thoracoscopic lung cancer lobectomy: a retrospective-cohort study
title_full_unstemmed Effects of degree of pulmonary fissure completeness on major in-hospital outcomes after video-assisted thoracoscopic lung cancer lobectomy: a retrospective-cohort study
title_short Effects of degree of pulmonary fissure completeness on major in-hospital outcomes after video-assisted thoracoscopic lung cancer lobectomy: a retrospective-cohort study
title_sort effects of degree of pulmonary fissure completeness on major in-hospital outcomes after video-assisted thoracoscopic lung cancer lobectomy: a retrospective-cohort study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841327/
https://www.ncbi.nlm.nih.gov/pubmed/29535528
http://dx.doi.org/10.2147/TCRM.S159632
work_keys_str_mv AT lishuangjiang effectsofdegreeofpulmonaryfissurecompletenessonmajorinhospitaloutcomesaftervideoassistedthoracoscopiclungcancerlobectomyaretrospectivecohortstudy
AT wangzhiqiang effectsofdegreeofpulmonaryfissurecompletenessonmajorinhospitaloutcomesaftervideoassistedthoracoscopiclungcancerlobectomyaretrospectivecohortstudy
AT zhoukun effectsofdegreeofpulmonaryfissurecompletenessonmajorinhospitaloutcomesaftervideoassistedthoracoscopiclungcancerlobectomyaretrospectivecohortstudy
AT wangyan effectsofdegreeofpulmonaryfissurecompletenessonmajorinhospitaloutcomesaftervideoassistedthoracoscopiclungcancerlobectomyaretrospectivecohortstudy
AT wuyanming effectsofdegreeofpulmonaryfissurecompletenessonmajorinhospitaloutcomesaftervideoassistedthoracoscopiclungcancerlobectomyaretrospectivecohortstudy
AT lipengfei effectsofdegreeofpulmonaryfissurecompletenessonmajorinhospitaloutcomesaftervideoassistedthoracoscopiclungcancerlobectomyaretrospectivecohortstudy
AT cheguowei effectsofdegreeofpulmonaryfissurecompletenessonmajorinhospitaloutcomesaftervideoassistedthoracoscopiclungcancerlobectomyaretrospectivecohortstudy