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Results of the national organised colorectal cancer screening program with FIT in Paris

In France, colorectal cancer (CRC) benefits from a nationwide screening program. The faecal immunochemical test (FIT) is being used since April 2015. The test is recommended in asymptomatic patients followed by a colonoscopy if positive for identification and treatment of colorectal lesions. We inve...

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Autores principales: Pellat, Anna, Deyra, Jacques, Coriat, Romain, Chaussade, Stanislas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841338/
https://www.ncbi.nlm.nih.gov/pubmed/29515157
http://dx.doi.org/10.1038/s41598-018-22481-9
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author Pellat, Anna
Deyra, Jacques
Coriat, Romain
Chaussade, Stanislas
author_facet Pellat, Anna
Deyra, Jacques
Coriat, Romain
Chaussade, Stanislas
author_sort Pellat, Anna
collection PubMed
description In France, colorectal cancer (CRC) benefits from a nationwide screening program. The faecal immunochemical test (FIT) is being used since April 2015. The test is recommended in asymptomatic patients followed by a colonoscopy if positive for identification and treatment of colorectal lesions. We investigate the CRC national organised screening program using FIT in Paris. We performed a retrospective observational study, collecting data from the screening program in Paris using the ADECA75 database. Rates of participation, numbers of positive FIT, detection rates and positive predictive values (PPV) for advanced adenomas (AA) and/or CRC were determined. Between 01/01/2016 and 30/06/2017, 620.227 Parisians were eligible and 409.340 were invited to participate to the program. A total of 88.796 participants (23%) performed the test with 3.839 positive tests (4.3%). In the positive test population, 2.706 out of 3.839 individuals (70.5%) performed the required colonoscopy with available reports. Histology reports were only available for 2.401 participants (88,7%). Regarding lesions, 733 (30,5%) and 205 patients (8.5%) had AA and CRC, respectively. Over 18 months of screening with FIT in Paris, the PPV is in line with expected results while the participation rate is below European recommendations.
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spelling pubmed-58413382018-03-13 Results of the national organised colorectal cancer screening program with FIT in Paris Pellat, Anna Deyra, Jacques Coriat, Romain Chaussade, Stanislas Sci Rep Article In France, colorectal cancer (CRC) benefits from a nationwide screening program. The faecal immunochemical test (FIT) is being used since April 2015. The test is recommended in asymptomatic patients followed by a colonoscopy if positive for identification and treatment of colorectal lesions. We investigate the CRC national organised screening program using FIT in Paris. We performed a retrospective observational study, collecting data from the screening program in Paris using the ADECA75 database. Rates of participation, numbers of positive FIT, detection rates and positive predictive values (PPV) for advanced adenomas (AA) and/or CRC were determined. Between 01/01/2016 and 30/06/2017, 620.227 Parisians were eligible and 409.340 were invited to participate to the program. A total of 88.796 participants (23%) performed the test with 3.839 positive tests (4.3%). In the positive test population, 2.706 out of 3.839 individuals (70.5%) performed the required colonoscopy with available reports. Histology reports were only available for 2.401 participants (88,7%). Regarding lesions, 733 (30,5%) and 205 patients (8.5%) had AA and CRC, respectively. Over 18 months of screening with FIT in Paris, the PPV is in line with expected results while the participation rate is below European recommendations. Nature Publishing Group UK 2018-03-07 /pmc/articles/PMC5841338/ /pubmed/29515157 http://dx.doi.org/10.1038/s41598-018-22481-9 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Pellat, Anna
Deyra, Jacques
Coriat, Romain
Chaussade, Stanislas
Results of the national organised colorectal cancer screening program with FIT in Paris
title Results of the national organised colorectal cancer screening program with FIT in Paris
title_full Results of the national organised colorectal cancer screening program with FIT in Paris
title_fullStr Results of the national organised colorectal cancer screening program with FIT in Paris
title_full_unstemmed Results of the national organised colorectal cancer screening program with FIT in Paris
title_short Results of the national organised colorectal cancer screening program with FIT in Paris
title_sort results of the national organised colorectal cancer screening program with fit in paris
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841338/
https://www.ncbi.nlm.nih.gov/pubmed/29515157
http://dx.doi.org/10.1038/s41598-018-22481-9
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