Low-fidelity Venezuelan equine encephalitis virus polymerase mutants to improve live-attenuated vaccine safety and efficacy

During RNA virus replication, there is the potential to incorporate mutations that affect virulence or pathogenesis. For live-attenuated vaccines, this has implications for stability, as replication may result in mutations that either restore the wild-type phenotype via reversion or compensate for t...

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Detalles Bibliográficos
Autores principales: Kautz, Tiffany F, Guerbois, Mathilde, Khanipov, Kamil, Patterson, Edward I, Langsjoen, Rose M, Yun, Ruimei, Warmbrod, Kelsey L, Fofanov, Yuriy, Weaver, Scott C, Forrester, Naomi L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841381/
https://www.ncbi.nlm.nih.gov/pubmed/29593882
http://dx.doi.org/10.1093/ve/vey004

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