Modulation of nuclear factor-kappa B activation by the endoplasmic reticulum stress sensor PERK to mediate estrogen-induced apoptosis in breast cancer cells

Stress responses are critical for estrogen (E(2))-induced apoptosis in E(2)-deprived breast cancer cells. Nuclear factor-kappa B (NF-κB) is an important therapeutic target to prevent stress responses in chronic inflammatory diseases including cancer. However, whether E(2) activates NF-κB to particip...

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Detalles Bibliográficos
Autores principales: Fan, Ping, Tyagi, Amit K., Agboke, Fadeke A., Mathur, Rohit, Pokharel, Niranjana, Jordan, V. Craig
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841410/
https://www.ncbi.nlm.nih.gov/pubmed/29531812
http://dx.doi.org/10.1038/s41420-017-0012-7

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