The CD14 (−159 C/T) SNP is associated with sCD14 levels and allergic asthma, but not with CD14 expression on monocytes

LPS-ligation to CD14/TLR-4 on monocytes/macrophages triggers the production of IL-12-family cytokines. IL12/18 promote TH(1)-differentiation, counteracting the TH(2)-driven asthma. Therefore, CD14 modulation could alter the TH(2)-differentiation and should be taken into account when studying asthma....

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Detalles Bibliográficos
Autores principales: Nieto-Fontarigo, J. J., Salgado, F. J., San-José, M. E., Cruz, M. J., Casas-Fernández, A., Gómez-Conde, M. J., Valdés-Cuadrado, L., García-González, M. Á., Arias, P., Nogueira, M., González-Barcala, F. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841440/
https://www.ncbi.nlm.nih.gov/pubmed/29515128
http://dx.doi.org/10.1038/s41598-018-20483-1

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