Anti-cancer characteristics and ototoxicity of platinum(II) amine complexes with only one leaving ligand

Unlike cisplatin, which forms bifunctional DNA adducts, monofunctional platinum(II) complexes bind only one strand of DNA and might target cancer without causing auditory side-effects associated with cisplatin treatment. We synthesized the monofunctional triamine-ligated platinum(II) complexes, Pt(d...

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Detalles Bibliográficos
Autores principales: Monroe, Jerry D., Hruska, Heidi L., Ruggles, Hannah K., Williams, Kevin M., Smith, Michael E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841658/
https://www.ncbi.nlm.nih.gov/pubmed/29513752
http://dx.doi.org/10.1371/journal.pone.0192505

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841658/
https://www.ncbi.nlm.nih.gov/pubmed/29513752
http://dx.doi.org/10.1371/journal.pone.0192505

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