Generation of iPSCs carrying a common LRRK2 risk allele for in vitro modeling of idiopathic Parkinson's disease

Induced pluripotent stem cells (iPSCs) have recapitulated several aspects of Parkinson’s disease (PD), but most iPSCs are derived from familial cases, which account for only about 15% of patients. Thus, while the emphasis has justifiably been on using iPSCs to model rare familial cases, models for t...

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Detalles Bibliográficos
Autores principales: Marrone, Lara, Bus, Christine, Schöndorf, David, Fitzgerald, Julia Catherine, Kübler, Manuela, Schmid, Benjamin, Reinhardt, Peter, Reinhardt, Lydia, Deleidi, Michela, Levin, Tanya, Meixner, Andrea, Klink, Barbara, Glatza, Michael, Gloeckner, Christian Johannes, Gasser, Thomas, Sterneckert, Jared
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841660/
https://www.ncbi.nlm.nih.gov/pubmed/29513666
http://dx.doi.org/10.1371/journal.pone.0192497

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