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Peripheral neuropathy in patients with multiple sclerosis

OBJECTIVES: To determine the prevalence and severity of neuropathic pain, sudomotor dysfunction and abnormal vibration perception in patients with MS. METHODS: 73 patients with MS and 32 age-matched healthy controls underwent assessment of expanded disability severity score (EDSS), DN4 to assess neu...

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Autores principales: Khan, Adnan, Kamran, Saadat, Ponirakis, Georgios, Akhtar, Naveed, Khan, Rabia, George, Pooja, Babu, Blessy M., Ibrahim, Faiza M., Petropoulos, Ioannis N., Canibano, Beatriz G., Wilins, Stacy S., Deleu, Dirk, Shuaib, Ashfaq, Malik, Rayaz A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841750/
https://www.ncbi.nlm.nih.gov/pubmed/29513761
http://dx.doi.org/10.1371/journal.pone.0193270
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author Khan, Adnan
Kamran, Saadat
Ponirakis, Georgios
Akhtar, Naveed
Khan, Rabia
George, Pooja
Babu, Blessy M.
Ibrahim, Faiza M.
Petropoulos, Ioannis N.
Canibano, Beatriz G.
Wilins, Stacy S.
Deleu, Dirk
Shuaib, Ashfaq
Malik, Rayaz A.
author_facet Khan, Adnan
Kamran, Saadat
Ponirakis, Georgios
Akhtar, Naveed
Khan, Rabia
George, Pooja
Babu, Blessy M.
Ibrahim, Faiza M.
Petropoulos, Ioannis N.
Canibano, Beatriz G.
Wilins, Stacy S.
Deleu, Dirk
Shuaib, Ashfaq
Malik, Rayaz A.
author_sort Khan, Adnan
collection PubMed
description OBJECTIVES: To determine the prevalence and severity of neuropathic pain, sudomotor dysfunction and abnormal vibration perception in patients with MS. METHODS: 73 patients with MS and 32 age-matched healthy controls underwent assessment of expanded disability severity score (EDSS), DN4 to assess neuropathic pain, electrochemical skin conductance (ESC) to assess sudomotor function and vibration perception threshold (VPT). RESULTS: Patients with MS had a higher DN4 score (p < 0.001) with 14% fulfilling the criteria for neuropathic pain elevated VPT (p < 0.001) and lower ESC on the feet (p < 0.001) and hands (p < 0.001) compared to control participants. ESC on the feet (32% of MS patients) and hands (30% of MS patients) were lower, and DN4 (77% of MS patients) and VPT (64% of MS patients) were greater than 2SD of the healthy control values, respectively. EDSS correlated with the number of relapses (r = 0.564, p < 0.001), VPT (r = –0.457, < 0.001) and ESC on the feet (r = –0.268, p = 0.023). CONCLUSIONS: Patients with multiple sclerosis have evidence of sudomotor dysfunction and elevated vibration perception, which were associated with neurological disability from MS.
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spelling pubmed-58417502018-03-23 Peripheral neuropathy in patients with multiple sclerosis Khan, Adnan Kamran, Saadat Ponirakis, Georgios Akhtar, Naveed Khan, Rabia George, Pooja Babu, Blessy M. Ibrahim, Faiza M. Petropoulos, Ioannis N. Canibano, Beatriz G. Wilins, Stacy S. Deleu, Dirk Shuaib, Ashfaq Malik, Rayaz A. PLoS One Research Article OBJECTIVES: To determine the prevalence and severity of neuropathic pain, sudomotor dysfunction and abnormal vibration perception in patients with MS. METHODS: 73 patients with MS and 32 age-matched healthy controls underwent assessment of expanded disability severity score (EDSS), DN4 to assess neuropathic pain, electrochemical skin conductance (ESC) to assess sudomotor function and vibration perception threshold (VPT). RESULTS: Patients with MS had a higher DN4 score (p < 0.001) with 14% fulfilling the criteria for neuropathic pain elevated VPT (p < 0.001) and lower ESC on the feet (p < 0.001) and hands (p < 0.001) compared to control participants. ESC on the feet (32% of MS patients) and hands (30% of MS patients) were lower, and DN4 (77% of MS patients) and VPT (64% of MS patients) were greater than 2SD of the healthy control values, respectively. EDSS correlated with the number of relapses (r = 0.564, p < 0.001), VPT (r = –0.457, < 0.001) and ESC on the feet (r = –0.268, p = 0.023). CONCLUSIONS: Patients with multiple sclerosis have evidence of sudomotor dysfunction and elevated vibration perception, which were associated with neurological disability from MS. Public Library of Science 2018-03-07 /pmc/articles/PMC5841750/ /pubmed/29513761 http://dx.doi.org/10.1371/journal.pone.0193270 Text en © 2018 Khan et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Khan, Adnan
Kamran, Saadat
Ponirakis, Georgios
Akhtar, Naveed
Khan, Rabia
George, Pooja
Babu, Blessy M.
Ibrahim, Faiza M.
Petropoulos, Ioannis N.
Canibano, Beatriz G.
Wilins, Stacy S.
Deleu, Dirk
Shuaib, Ashfaq
Malik, Rayaz A.
Peripheral neuropathy in patients with multiple sclerosis
title Peripheral neuropathy in patients with multiple sclerosis
title_full Peripheral neuropathy in patients with multiple sclerosis
title_fullStr Peripheral neuropathy in patients with multiple sclerosis
title_full_unstemmed Peripheral neuropathy in patients with multiple sclerosis
title_short Peripheral neuropathy in patients with multiple sclerosis
title_sort peripheral neuropathy in patients with multiple sclerosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841750/
https://www.ncbi.nlm.nih.gov/pubmed/29513761
http://dx.doi.org/10.1371/journal.pone.0193270
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