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Chloroquine augments TRAIL-induced apoptosis and induces G2/M phase arrest in human pancreatic cancer cells

Autophagy contributes to the treatment-resistance of many types of cancers, and chloroquine (CQ) inhibits autophagy. The tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) kills cancer cells but is minimally cytotoxic to normal cells. However, because the therapeutic efficacy of T...

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Detalles Bibliográficos
Autores principales:	Monma, Hiroyuki, Iida, Yuichi, Moritani, Tamami, Okimoto, Tamio, Tanino, Ryosuke, Tajima, Yoshitsugu, Harada, Mamoru
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841811/ https://www.ncbi.nlm.nih.gov/pubmed/29513749 http://dx.doi.org/10.1371/journal.pone.0193990

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