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A new perspective on the pathogenesis of chronic renal disease in captive cheetahs (Acinonyx jubatus)

The sustainability of captive cheetah populations is limited by high mortality due to chronic renal disease. This necropsy study, conducted on 243 captive cheetahs from one institution, investigated the relationships between focal palatine erosions, gastritis, enterocolitis, glomerulosclerosis, chro...

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Autores principales: Mitchell, Emily P., Prozesky, Leon, Lawrence, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841817/
https://www.ncbi.nlm.nih.gov/pubmed/29513736
http://dx.doi.org/10.1371/journal.pone.0194114
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author Mitchell, Emily P.
Prozesky, Leon
Lawrence, John
author_facet Mitchell, Emily P.
Prozesky, Leon
Lawrence, John
author_sort Mitchell, Emily P.
collection PubMed
description The sustainability of captive cheetah populations is limited by high mortality due to chronic renal disease. This necropsy study, conducted on 243 captive cheetahs from one institution, investigated the relationships between focal palatine erosions, gastritis, enterocolitis, glomerulosclerosis, chronic renal infarcts, renal cortical and medullary fibrosis, and renal medullary amyloidosis at death. Associations between the individual renal lesions and death due to chronic renal disease and comparisons of lesion prevalence between captive bred and wild born and between normal and king coated cheetahs were also assessed. All lesions were significantly positively correlated with age at death. Renal medullary fibrosis was the only lesion associated with the likelihood of death being due to chronic renal disease, and cheetahs with this lesion were younger, on average, than cheetahs with other renal lesions. Alimentary tract lesions were not associated with amyloidosis. All lesions, except for palatine erosions, were more common in wild born than in captive bred cheetahs; the former were older at death than the latter. Having a king coat had no clear effect on disease prevalence. These results suggest that age and renal medullary fibrosis are the primary factors influencing the pathogenesis of chronic renal disease in captive cheetahs. Apart from amyloidosis, these findings are analogous to those described in chronic renal disease in domestic cats, which is postulated to result primarily from repetitive hypoxic injury of renal tubules, mediated by age and stress. Cheetahs may be particularly susceptible to acute renal tubular injury due to their propensity for stress and their extended life span in captivity, as well as their adaptation for fecundity (rather than longevity) and adrenaline-mediated high speed prey chases. The presence of chronic renal disease in subadult cheetahs suggests that prevention, identification and mitigation of stress are critical to the successful prevention of chronic renal disease in captive cheetahs.
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spelling pubmed-58418172018-03-23 A new perspective on the pathogenesis of chronic renal disease in captive cheetahs (Acinonyx jubatus) Mitchell, Emily P. Prozesky, Leon Lawrence, John PLoS One Research Article The sustainability of captive cheetah populations is limited by high mortality due to chronic renal disease. This necropsy study, conducted on 243 captive cheetahs from one institution, investigated the relationships between focal palatine erosions, gastritis, enterocolitis, glomerulosclerosis, chronic renal infarcts, renal cortical and medullary fibrosis, and renal medullary amyloidosis at death. Associations between the individual renal lesions and death due to chronic renal disease and comparisons of lesion prevalence between captive bred and wild born and between normal and king coated cheetahs were also assessed. All lesions were significantly positively correlated with age at death. Renal medullary fibrosis was the only lesion associated with the likelihood of death being due to chronic renal disease, and cheetahs with this lesion were younger, on average, than cheetahs with other renal lesions. Alimentary tract lesions were not associated with amyloidosis. All lesions, except for palatine erosions, were more common in wild born than in captive bred cheetahs; the former were older at death than the latter. Having a king coat had no clear effect on disease prevalence. These results suggest that age and renal medullary fibrosis are the primary factors influencing the pathogenesis of chronic renal disease in captive cheetahs. Apart from amyloidosis, these findings are analogous to those described in chronic renal disease in domestic cats, which is postulated to result primarily from repetitive hypoxic injury of renal tubules, mediated by age and stress. Cheetahs may be particularly susceptible to acute renal tubular injury due to their propensity for stress and their extended life span in captivity, as well as their adaptation for fecundity (rather than longevity) and adrenaline-mediated high speed prey chases. The presence of chronic renal disease in subadult cheetahs suggests that prevention, identification and mitigation of stress are critical to the successful prevention of chronic renal disease in captive cheetahs. Public Library of Science 2018-03-07 /pmc/articles/PMC5841817/ /pubmed/29513736 http://dx.doi.org/10.1371/journal.pone.0194114 Text en © 2018 Mitchell et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Mitchell, Emily P.
Prozesky, Leon
Lawrence, John
A new perspective on the pathogenesis of chronic renal disease in captive cheetahs (Acinonyx jubatus)
title A new perspective on the pathogenesis of chronic renal disease in captive cheetahs (Acinonyx jubatus)
title_full A new perspective on the pathogenesis of chronic renal disease in captive cheetahs (Acinonyx jubatus)
title_fullStr A new perspective on the pathogenesis of chronic renal disease in captive cheetahs (Acinonyx jubatus)
title_full_unstemmed A new perspective on the pathogenesis of chronic renal disease in captive cheetahs (Acinonyx jubatus)
title_short A new perspective on the pathogenesis of chronic renal disease in captive cheetahs (Acinonyx jubatus)
title_sort new perspective on the pathogenesis of chronic renal disease in captive cheetahs (acinonyx jubatus)
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841817/
https://www.ncbi.nlm.nih.gov/pubmed/29513736
http://dx.doi.org/10.1371/journal.pone.0194114
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