Adult height, coronary heart disease and stroke: a multi-locus Mendelian randomization meta-analysis

Background: We investigated causal effect of completed growth, measured by adult height, on coronary heart disease (CHD), stroke and cardiovascular traits, using instrumental variable (IV) Mendelian randomization meta-analysis. Methods: We developed an allele score based on 69 single nucleotide poly...

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Detalles Bibliográficos
Autores principales: Nüesch, Eveline, Dale, Caroline, Palmer, Tom M, White, Jon, Keating, Brendan J, van Iperen, Erik PA, Goel, Anuj, Padmanabhan, Sandosh, Asselbergs, Folkert W, Verschuren, WM, Wijmenga, C, Van der Schouw, YT, Onland-Moret, NC, Lange, Leslie A, Hovingh, GK, Sivapalaratnam, Suthesh, Morris, Richard W, Whincup, Peter H, Wannamethe, Goya S, Gaunt, Tom R, Ebrahim, Shah, Steel, Laura, Nair, Nikhil, Reiner, Alexander P, Kooperberg, Charles, Wilson, James F, Bolton, Jennifer L, McLachlan, Stela, Price, Jacqueline F, Strachan, Mark WJ, Robertson, Christine M, Kleber, Marcus E, Delgado, Graciela, März, Winfried, Melander, Olle, Dominiczak, Anna F, Farrall, Martin, Watkins, Hugh, Leusink, Maarten, Maitland-van der Zee, Anke H, de Groot, Mark CH, Dudbridge, Frank, Hingorani, Aroon, Ben-Shlomo, Yoav, Lawlor, Debbie A, Amuzu, A, Caufield, M, Cavadino, A, Cooper, J, Davies, TL, Drenos, F, Engmann, J, Finan, C, Giambartolomei, C, Hardy, R, Humphries, SE, Hypponen, E, Kivimaki, M, Kuh, D, Kumari, M, Ong, K, Plagnol, V, Power, C, Richards, M, Shah, S, Shah, T, Sofat, R, Talmud, PJ, Wareham, N, Warren, H, Whittaker, JC, Wong, A, Zabaneh, D, Davey Smith, George, Wells, Jonathan C, Leon, David A, Holmes, Michael V, Casas, Juan P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Mendelian Randomisation and Instrumental Variable Analysis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841831/
https://www.ncbi.nlm.nih.gov/pubmed/25979724
http://dx.doi.org/10.1093/ije/dyv074

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