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Management of prostacyclin side effects in adult patients with pulmonary arterial hypertension

Therapies that target the prostacyclin pathway are considered effective, yet are complex to dose and may cause dose-limiting side effects for patients with pulmonary arterial hypertension (PAH). Careful side effect management and the ability to discern side effects from worsening disease are essenti...

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Autores principales: Kingman, Martha, Archer-Chicko, Christine, Bartlett, Mary, Beckmann, Joy, Hohsfield, Robin, Lombardi, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841898/
https://www.ncbi.nlm.nih.gov/pubmed/28632002
http://dx.doi.org/10.1177/2045893217719250
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author Kingman, Martha
Archer-Chicko, Christine
Bartlett, Mary
Beckmann, Joy
Hohsfield, Robin
Lombardi, Sandra
author_facet Kingman, Martha
Archer-Chicko, Christine
Bartlett, Mary
Beckmann, Joy
Hohsfield, Robin
Lombardi, Sandra
author_sort Kingman, Martha
collection PubMed
description Therapies that target the prostacyclin pathway are considered effective, yet are complex to dose and may cause dose-limiting side effects for patients with pulmonary arterial hypertension (PAH). Careful side effect management and the ability to discern side effects from worsening disease are essential in order for patients to continue, and benefit from, prostacyclin therapy. This manuscript was developed through a collaborative effort of allied health providers with extensive experience in managing patients with PAH who are treated with medications that target the prostacyclin pathway. This article provides an overview of individual prostacyclin pathway therapies approved in the United States, side effects most commonly associated with these therapies, and practical suggestions for side effect management. Most patients will experience significant side effects on prostacyclin therapy. Creating a proactive and careful side effect management program will increase the likelihood that patients are able to stay on therapy and receive the benefits afforded by prostacyclin therapy.
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spelling pubmed-58418982018-03-12 Management of prostacyclin side effects in adult patients with pulmonary arterial hypertension Kingman, Martha Archer-Chicko, Christine Bartlett, Mary Beckmann, Joy Hohsfield, Robin Lombardi, Sandra Pulm Circ Review Articles Therapies that target the prostacyclin pathway are considered effective, yet are complex to dose and may cause dose-limiting side effects for patients with pulmonary arterial hypertension (PAH). Careful side effect management and the ability to discern side effects from worsening disease are essential in order for patients to continue, and benefit from, prostacyclin therapy. This manuscript was developed through a collaborative effort of allied health providers with extensive experience in managing patients with PAH who are treated with medications that target the prostacyclin pathway. This article provides an overview of individual prostacyclin pathway therapies approved in the United States, side effects most commonly associated with these therapies, and practical suggestions for side effect management. Most patients will experience significant side effects on prostacyclin therapy. Creating a proactive and careful side effect management program will increase the likelihood that patients are able to stay on therapy and receive the benefits afforded by prostacyclin therapy. SAGE Publications 2017-07-11 /pmc/articles/PMC5841898/ /pubmed/28632002 http://dx.doi.org/10.1177/2045893217719250 Text en © The Author(s) 2017 http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review Articles
Kingman, Martha
Archer-Chicko, Christine
Bartlett, Mary
Beckmann, Joy
Hohsfield, Robin
Lombardi, Sandra
Management of prostacyclin side effects in adult patients with pulmonary arterial hypertension
title Management of prostacyclin side effects in adult patients with pulmonary arterial hypertension
title_full Management of prostacyclin side effects in adult patients with pulmonary arterial hypertension
title_fullStr Management of prostacyclin side effects in adult patients with pulmonary arterial hypertension
title_full_unstemmed Management of prostacyclin side effects in adult patients with pulmonary arterial hypertension
title_short Management of prostacyclin side effects in adult patients with pulmonary arterial hypertension
title_sort management of prostacyclin side effects in adult patients with pulmonary arterial hypertension
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841898/
https://www.ncbi.nlm.nih.gov/pubmed/28632002
http://dx.doi.org/10.1177/2045893217719250
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