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Do single or sequential measurements of leptin and adiponectin in plasma have prognostic value in pulmonary arterial hypertension?

Leptin (a neuroendocrine peptide that enhances metabolism and acts on the hypothalamus to suppress appetite) and adiponectin (a protein that has insulin-sensitizing, anti-inflammatory, and antiproliferative properties) are involved in the pathobiology of pulmonary arterial hypertension (PAH). We hyp...

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Autores principales: Tonelli, Adriano R., Fares, Wassim H., Dakkak, Wael, Rao, Youlan, Zhou, Xuan, Dweik, Raed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841903/
https://www.ncbi.nlm.nih.gov/pubmed/28604281
http://dx.doi.org/10.1177/2045893217717219
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author Tonelli, Adriano R.
Fares, Wassim H.
Dakkak, Wael
Rao, Youlan
Zhou, Xuan
Dweik, Raed A.
author_facet Tonelli, Adriano R.
Fares, Wassim H.
Dakkak, Wael
Rao, Youlan
Zhou, Xuan
Dweik, Raed A.
author_sort Tonelli, Adriano R.
collection PubMed
description Leptin (a neuroendocrine peptide that enhances metabolism and acts on the hypothalamus to suppress appetite) and adiponectin (a protein that has insulin-sensitizing, anti-inflammatory, and antiproliferative properties) are involved in the pathobiology of pulmonary arterial hypertension (PAH). We hypothesized that plasma leptin and adiponectin as well as the leptin/adiponectin ratio are abnormal in PAH patients and their levels track with disease severity and functional changes during follow-up. We tested this hypothesis in a cohort of patients included in the 16-week, international, multicenter, double-blind, placebo-controlled FREEDOM-C2 study. Blood was collected at baseline and week 16 in 178 out of 310 randomized patients with PAH. Baseline plasma leptin and adiponectin concentrations were 25 ± 31 ng/mL and 7.8 ± 6.1 ug/mL, respectively. Leptin, adiponectin, and leptin/adiponectin (mean ± SD) changes at 16 week were of small magnitude. Leptin at baseline was significantly associated with older age, higher BMI, higher Borg dyspnea index, and lower NT-pro BNP. Women had higher levels of leptin than men (30.5 ± 33.2 versus 7.2 ± 6.4 ng/mL), even when adjusting for background therapy and etiology (linear regression: β = 21.8, P < 0.001). Adiponectin was negatively associated with BMI and positively associated with NT-pro BNP. Changes in leptin, adiponectin, and leptin/adiponectin ratio adjusted for weight at 16 weeks did not predict functional class, distance walk in 6 min or survival at one, two, three, or four years. Plasma leptin and adiponectin at baseline and their change at 16-week do not appear to significantly impact prognosis in PAH.
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spelling pubmed-58419032018-03-12 Do single or sequential measurements of leptin and adiponectin in plasma have prognostic value in pulmonary arterial hypertension? Tonelli, Adriano R. Fares, Wassim H. Dakkak, Wael Rao, Youlan Zhou, Xuan Dweik, Raed A. Pulm Circ Research Articles Leptin (a neuroendocrine peptide that enhances metabolism and acts on the hypothalamus to suppress appetite) and adiponectin (a protein that has insulin-sensitizing, anti-inflammatory, and antiproliferative properties) are involved in the pathobiology of pulmonary arterial hypertension (PAH). We hypothesized that plasma leptin and adiponectin as well as the leptin/adiponectin ratio are abnormal in PAH patients and their levels track with disease severity and functional changes during follow-up. We tested this hypothesis in a cohort of patients included in the 16-week, international, multicenter, double-blind, placebo-controlled FREEDOM-C2 study. Blood was collected at baseline and week 16 in 178 out of 310 randomized patients with PAH. Baseline plasma leptin and adiponectin concentrations were 25 ± 31 ng/mL and 7.8 ± 6.1 ug/mL, respectively. Leptin, adiponectin, and leptin/adiponectin (mean ± SD) changes at 16 week were of small magnitude. Leptin at baseline was significantly associated with older age, higher BMI, higher Borg dyspnea index, and lower NT-pro BNP. Women had higher levels of leptin than men (30.5 ± 33.2 versus 7.2 ± 6.4 ng/mL), even when adjusting for background therapy and etiology (linear regression: β = 21.8, P < 0.001). Adiponectin was negatively associated with BMI and positively associated with NT-pro BNP. Changes in leptin, adiponectin, and leptin/adiponectin ratio adjusted for weight at 16 weeks did not predict functional class, distance walk in 6 min or survival at one, two, three, or four years. Plasma leptin and adiponectin at baseline and their change at 16-week do not appear to significantly impact prognosis in PAH. SAGE Publications 2017-06-27 /pmc/articles/PMC5841903/ /pubmed/28604281 http://dx.doi.org/10.1177/2045893217717219 Text en © The Author(s) 2017 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Research Articles
Tonelli, Adriano R.
Fares, Wassim H.
Dakkak, Wael
Rao, Youlan
Zhou, Xuan
Dweik, Raed A.
Do single or sequential measurements of leptin and adiponectin in plasma have prognostic value in pulmonary arterial hypertension?
title Do single or sequential measurements of leptin and adiponectin in plasma have prognostic value in pulmonary arterial hypertension?
title_full Do single or sequential measurements of leptin and adiponectin in plasma have prognostic value in pulmonary arterial hypertension?
title_fullStr Do single or sequential measurements of leptin and adiponectin in plasma have prognostic value in pulmonary arterial hypertension?
title_full_unstemmed Do single or sequential measurements of leptin and adiponectin in plasma have prognostic value in pulmonary arterial hypertension?
title_short Do single or sequential measurements of leptin and adiponectin in plasma have prognostic value in pulmonary arterial hypertension?
title_sort do single or sequential measurements of leptin and adiponectin in plasma have prognostic value in pulmonary arterial hypertension?
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841903/
https://www.ncbi.nlm.nih.gov/pubmed/28604281
http://dx.doi.org/10.1177/2045893217717219
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