Association of the SOD2 Polymorphism (Val16Ala) and SOD Activity with Vaso-occlusive Crisis and Acute Splenic Sequestration in Children with Sickle Cell Anemia

The SOD2 polymorphism Val16Ala T→C influences the antioxidative response. This study investigated the association of the SOD2 polymorphism and superoxide dismutase (SOD) activity with the vaso-occlusive crisis (VOC) and acute splenic sequestration (ASS) in children with sickle cell anemia (SCA). One...

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Detalles Bibliográficos
Autores principales: Farias, Isabela Cristina Cordeiro, Mendonça-Belmont, Taciana Furtado, da Silva, Andreia Soares, do Ó, Kleyton Palmeira, Ferreira, Felipe, Medeiros, Fernanda Silva, da Silva Vasconcelos, Luydson Richardson, Bezerra, Marcos André Cavalcanti, da Silva Araújo, Aderson, de Moura, Patricia Muniz Mendes Freire, Hatzlhofer, Betânia Lucena Domingues, dos Anjos, Ana Claudia Mendonça, de Mendonça Cavalcanti, Maria do Socorro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Università Cattolica del Sacro Cuore 2018
Materias:
Scientific Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841937/
https://www.ncbi.nlm.nih.gov/pubmed/29531649
http://dx.doi.org/10.4084/MJHID.2018.012
Descripción
Sumario:The SOD2 polymorphism Val16Ala T→C influences the antioxidative response. This study investigated the association of the SOD2 polymorphism and superoxide dismutase (SOD) activity with the vaso-occlusive crisis (VOC) and acute splenic sequestration (ASS) in children with sickle cell anemia (SCA). One hundred ninety-five children with SCA aged 1–9 years old were analyzed. The TC and CC genotypes were associated with lower SOD activity compared with the TT genotype (p=0.0321; p=0.0253, respectively). Furthermore, TC and CC were more frequent in patients with VOC or ASS (p=0.0285; p=0.0090, respectively). These results suggest that the SOD2 polymorphism associated with low SOD activity could be a susceptibility factor for the occurrence of VOC and ASS.

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