Association of the SOD2 Polymorphism (Val16Ala) and SOD Activity with Vaso-occlusive Crisis and Acute Splenic Sequestration in Children with Sickle Cell Anemia

The SOD2 polymorphism Val16Ala T→C influences the antioxidative response. This study investigated the association of the SOD2 polymorphism and superoxide dismutase (SOD) activity with the vaso-occlusive crisis (VOC) and acute splenic sequestration (ASS) in children with sickle cell anemia (SCA). One...

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Autores principales: Farias, Isabela Cristina Cordeiro, Mendonça-Belmont, Taciana Furtado, da Silva, Andreia Soares, do Ó, Kleyton Palmeira, Ferreira, Felipe, Medeiros, Fernanda Silva, da Silva Vasconcelos, Luydson Richardson, Bezerra, Marcos André Cavalcanti, da Silva Araújo, Aderson, de Moura, Patricia Muniz Mendes Freire, Hatzlhofer, Betânia Lucena Domingues, dos Anjos, Ana Claudia Mendonça, de Mendonça Cavalcanti, Maria do Socorro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Università Cattolica del Sacro Cuore 2018
Materias:
Scientific Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841937/
https://www.ncbi.nlm.nih.gov/pubmed/29531649
http://dx.doi.org/10.4084/MJHID.2018.012
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author Farias, Isabela Cristina Cordeiro
Mendonça-Belmont, Taciana Furtado
da Silva, Andreia Soares
do Ó, Kleyton Palmeira
Ferreira, Felipe
Medeiros, Fernanda Silva
da Silva Vasconcelos, Luydson Richardson
Bezerra, Marcos André Cavalcanti
da Silva Araújo, Aderson
de Moura, Patricia Muniz Mendes Freire
Hatzlhofer, Betânia Lucena Domingues
dos Anjos, Ana Claudia Mendonça
de Mendonça Cavalcanti, Maria do Socorro
author_facet Farias, Isabela Cristina Cordeiro
Mendonça-Belmont, Taciana Furtado
da Silva, Andreia Soares
do Ó, Kleyton Palmeira
Ferreira, Felipe
Medeiros, Fernanda Silva
da Silva Vasconcelos, Luydson Richardson
Bezerra, Marcos André Cavalcanti
da Silva Araújo, Aderson
de Moura, Patricia Muniz Mendes Freire
Hatzlhofer, Betânia Lucena Domingues
dos Anjos, Ana Claudia Mendonça
de Mendonça Cavalcanti, Maria do Socorro
author_sort Farias, Isabela Cristina Cordeiro
collection PubMed
description The SOD2 polymorphism Val16Ala T→C influences the antioxidative response. This study investigated the association of the SOD2 polymorphism and superoxide dismutase (SOD) activity with the vaso-occlusive crisis (VOC) and acute splenic sequestration (ASS) in children with sickle cell anemia (SCA). One hundred ninety-five children with SCA aged 1–9 years old were analyzed. The TC and CC genotypes were associated with lower SOD activity compared with the TT genotype (p=0.0321; p=0.0253, respectively). Furthermore, TC and CC were more frequent in patients with VOC or ASS (p=0.0285; p=0.0090, respectively). These results suggest that the SOD2 polymorphism associated with low SOD activity could be a susceptibility factor for the occurrence of VOC and ASS.
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spelling pubmed-58419372018-03-12 Association of the SOD2 Polymorphism (Val16Ala) and SOD Activity with Vaso-occlusive Crisis and Acute Splenic Sequestration in Children with Sickle Cell Anemia Farias, Isabela Cristina Cordeiro Mendonça-Belmont, Taciana Furtado da Silva, Andreia Soares do Ó, Kleyton Palmeira Ferreira, Felipe Medeiros, Fernanda Silva da Silva Vasconcelos, Luydson Richardson Bezerra, Marcos André Cavalcanti da Silva Araújo, Aderson de Moura, Patricia Muniz Mendes Freire Hatzlhofer, Betânia Lucena Domingues dos Anjos, Ana Claudia Mendonça de Mendonça Cavalcanti, Maria do Socorro Mediterr J Hematol Infect Dis Scientific Letter The SOD2 polymorphism Val16Ala T→C influences the antioxidative response. This study investigated the association of the SOD2 polymorphism and superoxide dismutase (SOD) activity with the vaso-occlusive crisis (VOC) and acute splenic sequestration (ASS) in children with sickle cell anemia (SCA). One hundred ninety-five children with SCA aged 1–9 years old were analyzed. The TC and CC genotypes were associated with lower SOD activity compared with the TT genotype (p=0.0321; p=0.0253, respectively). Furthermore, TC and CC were more frequent in patients with VOC or ASS (p=0.0285; p=0.0090, respectively). These results suggest that the SOD2 polymorphism associated with low SOD activity could be a susceptibility factor for the occurrence of VOC and ASS. Università Cattolica del Sacro Cuore 2018-02-21 /pmc/articles/PMC5841937/ /pubmed/29531649 http://dx.doi.org/10.4084/MJHID.2018.012 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Scientific Letter
Farias, Isabela Cristina Cordeiro
Mendonça-Belmont, Taciana Furtado
da Silva, Andreia Soares
do Ó, Kleyton Palmeira
Ferreira, Felipe
Medeiros, Fernanda Silva
da Silva Vasconcelos, Luydson Richardson
Bezerra, Marcos André Cavalcanti
da Silva Araújo, Aderson
de Moura, Patricia Muniz Mendes Freire
Hatzlhofer, Betânia Lucena Domingues
dos Anjos, Ana Claudia Mendonça
de Mendonça Cavalcanti, Maria do Socorro
Association of the SOD2 Polymorphism (Val16Ala) and SOD Activity with Vaso-occlusive Crisis and Acute Splenic Sequestration in Children with Sickle Cell Anemia
title Association of the SOD2 Polymorphism (Val16Ala) and SOD Activity with Vaso-occlusive Crisis and Acute Splenic Sequestration in Children with Sickle Cell Anemia
title_full Association of the SOD2 Polymorphism (Val16Ala) and SOD Activity with Vaso-occlusive Crisis and Acute Splenic Sequestration in Children with Sickle Cell Anemia
title_fullStr Association of the SOD2 Polymorphism (Val16Ala) and SOD Activity with Vaso-occlusive Crisis and Acute Splenic Sequestration in Children with Sickle Cell Anemia
title_full_unstemmed Association of the SOD2 Polymorphism (Val16Ala) and SOD Activity with Vaso-occlusive Crisis and Acute Splenic Sequestration in Children with Sickle Cell Anemia
title_short Association of the SOD2 Polymorphism (Val16Ala) and SOD Activity with Vaso-occlusive Crisis and Acute Splenic Sequestration in Children with Sickle Cell Anemia
title_sort association of the sod2 polymorphism (val16ala) and sod activity with vaso-occlusive crisis and acute splenic sequestration in children with sickle cell anemia
topic Scientific Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841937/
https://www.ncbi.nlm.nih.gov/pubmed/29531649
http://dx.doi.org/10.4084/MJHID.2018.012
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