Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles

Binding of programmed death ligand-1 (PD-L1) to programmed cell death protein-1 (PD1) leads to cancer immune evasion via inhibition of T cell function. One of the defining characteristics of glioblastoma, a universally fatal brain cancer, is its profound local and systemic immunosuppression. Gliobla...

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Detalles Bibliográficos
Autores principales: Ricklefs, Franz L., Alayo, Quazim, Krenzlin, Harald, Mahmoud, Ahmad B., Speranza, Maria C., Nakashima, Hiroshi, Hayes, Josie L., Lee, Kyungheon, Balaj, Leonora, Passaro, Carmela, Rooj, Arun K., Krasemann, Susanne, Carter, Bob S., Chen, Clark C., Steed, Tyler, Treiber, Jeffrey, Rodig, Scott, Yang, Katherine, Nakano, Ichiro, Lee, Hakho, Weissleder, Ralph, Breakefield, Xandra O., Godlewski, Jakub, Westphal, Manfred, Lamszus, Katrin, Freeman, Gordon J., Bronisz, Agnieszka, Lawler, Sean E., Chiocca, E. Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842038/
https://www.ncbi.nlm.nih.gov/pubmed/29532035
http://dx.doi.org/10.1126/sciadv.aar2766

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