Mechanisms of KCNQ1 channel dysfunction in long QT syndrome involving voltage sensor domain mutations

Mutations that induce loss of function (LOF) or dysfunction of the human KCNQ1 channel are responsible for susceptibility to a life-threatening heart rhythm disorder, the congenital long QT syndrome (LQTS). Hundreds of KCNQ1 mutations have been identified, but the molecular mechanisms responsible fo...

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Detalles Bibliográficos
Autores principales: Huang, Hui, Kuenze, Georg, Smith, Jarrod A., Taylor, Keenan C., Duran, Amanda M., Hadziselimovic, Arina, Meiler, Jens, Vanoye, Carlos G., George, Alfred L., Sanders, Charles R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842040/
https://www.ncbi.nlm.nih.gov/pubmed/29532034
http://dx.doi.org/10.1126/sciadv.aar2631

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