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Early disseminated recurrence after liver resection in solitary hepatocellular carcinoma

PURPOSE: Although few hepatectomy patients develop unexpected early diffuse and multinodular recurrence in the remnant liver, the prognosis in such cases is often dismal. The aim of this study was to evaluate the risk factors of early disseminated multinodular hepatocellular carcinoma (HCC) recurren...

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Autores principales: Kim, Jong Man, Yi, Nam-Joon, Kwon, Choon Hyuck David, Lee, Kwang-Woong, Suh, Kyung-Suk, Joh, Jae-Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Surgical Society 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842084/
https://www.ncbi.nlm.nih.gov/pubmed/29520346
http://dx.doi.org/10.4174/astr.2018.94.3.129
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author Kim, Jong Man
Yi, Nam-Joon
Kwon, Choon Hyuck David
Lee, Kwang-Woong
Suh, Kyung-Suk
Joh, Jae-Won
author_facet Kim, Jong Man
Yi, Nam-Joon
Kwon, Choon Hyuck David
Lee, Kwang-Woong
Suh, Kyung-Suk
Joh, Jae-Won
author_sort Kim, Jong Man
collection PubMed
description PURPOSE: Although few hepatectomy patients develop unexpected early diffuse and multinodular recurrence in the remnant liver, the prognosis in such cases is often dismal. The aim of this study was to evaluate the risk factors of early disseminated multinodular hepatocellular carcinoma (HCC) recurrence within 3 months after liver resection for solitary HCC. METHODS: Eighty-four patients who were diagnosed with recurrent HCC within 3 months after hepatectomy for solitary HCC were retrospectively reviewed. Disseminated HCC recurrence was defined as more than 10 tumors in both lobes and total tumor size >10 cm. RESULTS: Preoperative α-FP level, incidence of poor tumor grade, and presence of portal vein tumor thrombosis were higher in the patients with disseminated HCC recurrence than in those without disseminated HCC recurrence (P < 0.05). Multivariate analysis showed that α-FP >1,000 ng/dL was a predisposing factor of disseminated HCC recurrence within 3 months after liver resection. The overall survival rate for patients without disseminated HCC recurrence was higher than that for patients with disseminated HCC recurrence (P < 0.001). CONCLUSION: Early disseminated multinodular HCC recurrence in hepatectomy patients was associated with preoperative α-FP >1,000 ng/dL. Such patients should be frequently evaluated for the early detection of recurrent HCC for early intervention.
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spelling pubmed-58420842018-03-08 Early disseminated recurrence after liver resection in solitary hepatocellular carcinoma Kim, Jong Man Yi, Nam-Joon Kwon, Choon Hyuck David Lee, Kwang-Woong Suh, Kyung-Suk Joh, Jae-Won Ann Surg Treat Res Original Article PURPOSE: Although few hepatectomy patients develop unexpected early diffuse and multinodular recurrence in the remnant liver, the prognosis in such cases is often dismal. The aim of this study was to evaluate the risk factors of early disseminated multinodular hepatocellular carcinoma (HCC) recurrence within 3 months after liver resection for solitary HCC. METHODS: Eighty-four patients who were diagnosed with recurrent HCC within 3 months after hepatectomy for solitary HCC were retrospectively reviewed. Disseminated HCC recurrence was defined as more than 10 tumors in both lobes and total tumor size >10 cm. RESULTS: Preoperative α-FP level, incidence of poor tumor grade, and presence of portal vein tumor thrombosis were higher in the patients with disseminated HCC recurrence than in those without disseminated HCC recurrence (P < 0.05). Multivariate analysis showed that α-FP >1,000 ng/dL was a predisposing factor of disseminated HCC recurrence within 3 months after liver resection. The overall survival rate for patients without disseminated HCC recurrence was higher than that for patients with disseminated HCC recurrence (P < 0.001). CONCLUSION: Early disseminated multinodular HCC recurrence in hepatectomy patients was associated with preoperative α-FP >1,000 ng/dL. Such patients should be frequently evaluated for the early detection of recurrent HCC for early intervention. The Korean Surgical Society 2018-03 2018-02-28 /pmc/articles/PMC5842084/ /pubmed/29520346 http://dx.doi.org/10.4174/astr.2018.94.3.129 Text en Copyright © 2018, the Korean Surgical Society http://creativecommons.org/licenses/by-nc/4.0/ Annals of Surgical Treatment and Research is an Open Access Journal. All articles are distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Jong Man
Yi, Nam-Joon
Kwon, Choon Hyuck David
Lee, Kwang-Woong
Suh, Kyung-Suk
Joh, Jae-Won
Early disseminated recurrence after liver resection in solitary hepatocellular carcinoma
title Early disseminated recurrence after liver resection in solitary hepatocellular carcinoma
title_full Early disseminated recurrence after liver resection in solitary hepatocellular carcinoma
title_fullStr Early disseminated recurrence after liver resection in solitary hepatocellular carcinoma
title_full_unstemmed Early disseminated recurrence after liver resection in solitary hepatocellular carcinoma
title_short Early disseminated recurrence after liver resection in solitary hepatocellular carcinoma
title_sort early disseminated recurrence after liver resection in solitary hepatocellular carcinoma
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842084/
https://www.ncbi.nlm.nih.gov/pubmed/29520346
http://dx.doi.org/10.4174/astr.2018.94.3.129
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