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Colorectal cancer liver metastases organoids retain characteristics of original tumor and acquire chemotherapy resistance
BACKGROUND: Colorectal cancer (CRC) liver metastasis is highly unfavorable for patient outcome and is a leading cause of cancer-related death. Pre-clinical research of CRC liver metastasis predominately utilizes CRC cell lines grown in tissue culture. Here, we demonstrate that CRC liver metastases o...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842239/ https://www.ncbi.nlm.nih.gov/pubmed/29414601 http://dx.doi.org/10.1016/j.scr.2018.01.016 |